TOP3B (DNA topoisomerase III beta)

2003-05-01  

Identity

HGNC
TOP3B
LOCATION
22q11.22
LOCUSID
8940
ALIAS
TOP3B1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8940
MIM: 603582
HGNC: 11993
Ensembl: ENSG00000100038

Variants:

dbSNP: 8940
ClinVar: 8940
TCGA: ENSG00000100038
COSMIC: TOP3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100038ENST00000357179O95985
ENSG00000100038ENST00000357179A0A024R1C2
ENSG00000100038ENST00000398793O95985
ENSG00000100038ENST00000398793A0A024R1C2
ENSG00000100038ENST00000424393C9JEI7
ENSG00000100038ENST00000430142C9JKE2
ENSG00000100038ENST00000434517C9JF56
ENSG00000100038ENST00000436282H7C4B0
ENSG00000100038ENST00000437103C9JTQ7
ENSG00000100038ENST00000437929C9JT00
ENSG00000100038ENST00000442653C9JHR0
ENSG00000100038ENST00000444502F2Z2A5
ENSG00000100038ENST00000449704C9JEQ1
ENSG00000100038ENST00000456075C9J9X4
ENSG00000100038ENST00000457179F2Z2A5
ENSG00000100038ENST00000457270H0Y6W0

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Bloom's syndrome complexKEGGhsa_M00414
Bloom's syndrome complexKEGGM00414

References

Pubmed IDYearTitleCitations
357488722022A dual-activity topoisomerase complex regulates mRNA translation and turnover.8
359454192022Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β.6
357488722022A dual-activity topoisomerase complex regulates mRNA translation and turnover.8
359454192022Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β.6
320280442020Further evidence of GABRA4 and TOP3B as autism susceptibility genes.10
327359002020Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses.19
333786762020DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.24
320280442020Further evidence of GABRA4 and TOP3B as autism susceptibility genes.10
327359002020Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses.19
333786762020DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.24
317959192019Loss of TOP3B leads to increased R-loop formation and genome instability.31
317959192019Loss of TOP3B leads to increased R-loop formation and genome instability.31
294714952018Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.41
294902922018TOP3B: A Novel Candidate Gene in Juvenile Myoclonic Epilepsy?13
294714952018Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.41

Citation

Dessen P

TOP3B (DNA topoisomerase III beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42661/css/lib/meetings/