TRIM25 (tripartite motif containing 25)

2003-02-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
EFP,RNF147,Z147,ZNF147
FUSION GENES

Other Information

Locus ID:

NCBI: 7706
MIM: 600453
HGNC: 12932
Ensembl: ENSG00000121060

Variants:

dbSNP: 7706
ClinVar: 7706
TCGA: ENSG00000121060
COSMIC: TRIM25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121060ENST00000316881Q14258
ENSG00000121060ENST00000537230Q14258
ENSG00000121060ENST00000572021I3L2W4
ENSG00000121060ENST00000648772A0A3B3IUA7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Influenza AKEGGko05164
Influenza AKEGGhsa05164
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373679952024TRIM25 inhibition attenuates inflammation, senescence, and oxidative stress in microvascular endothelial cells induced by hyperglycemia.1
379272172024Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.2
381536962024LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1.0
383030292024TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO.1
384383462024Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis.1
373679952024TRIM25 inhibition attenuates inflammation, senescence, and oxidative stress in microvascular endothelial cells induced by hyperglycemia.1
379272172024Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25.2
381536962024LncRNA CARD8-AS1 suppresses lung adenocarcinoma progression by enhancing TRIM25-mediated ubiquitination of TXNRD1.0
383030292024TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO.1
384383462024Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis.1
365769602023TRIM25 mutation (p.C168*), coding for an E3 ubiquitin ligase, is a cause of early-onset autosomal dominant dementia with amyloid load and parkinsonism.3
366119952023The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1.1
366354992023Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis.5
371887372023TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.2
373026962023TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells.3

Citation

Dessen P

TRIM25 (tripartite motif containing 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42698/css/lib/haematological-explorer/gene-explorer/