TTK (TTK protein kinase)

2003-11-01  

Identity

HGNC
TTK
LOCATION
6q14.1
LOCUSID
7272
ALIAS
CT96,ESK,MPH1,MPS1,MPS1L1,PYT

Other Information

Locus ID:

NCBI: 7272
MIM: 604092
HGNC: 12401
Ensembl: ENSG00000112742

Variants:

dbSNP: 7272
ClinVar: 7272
TCGA: ENSG00000112742
COSMIC: TTK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112742ENST00000230510P33981
ENSG00000112742ENST00000369798P33981
ENSG00000112742ENST00000502580D6RF82
ENSG00000112742ENST00000504040D6RIC6
ENSG00000112742ENST00000509313D6RFY1
ENSG00000112742ENST00000509894P33981
ENSG00000112742ENST00000511260D6REX1
ENSG00000112742ENST00000627129D6RFY1

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378158942023TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer.0
378949422023CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer.1
378158942023TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer.0
378949422023CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer.1
347676692022Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.3
348461572022TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.6
358507532022TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.4
347676692022Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.3
348461572022TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.6
358507532022TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.4
336277872021Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.18
341875562021Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.8
342664262021Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway.1
344562162021Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.1
345163422021TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.7

Citation

Dessen P

TTK (TTK protein kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42725