TYMS (thymidylate synthetase)

2003-08-01  

Identity

HGNC
TYMS
LOCATION
18p11.32
LOCUSID
7298
ALIAS
HST422,TMS,TS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7298
MIM: 188350
HGNC: 12441
Ensembl: ENSG00000176890

Variants:

dbSNP: 7298
ClinVar: 7298
TCGA: ENSG00000176890
COSMIC: TYMS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176890ENST00000323224P04818
ENSG00000176890ENST00000323250P04818
ENSG00000176890ENST00000323274P04818
ENSG00000176890ENST00000323274Q53Y97

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
One carbon pool by folateKEGGko00670
Pyrimidine metabolismKEGGhsa00240
One carbon pool by folateKEGGhsa00670
Metabolic pathwaysKEGGhsa01100
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
G1/S-Specific TranscriptionREACTOMER-HSA-69205
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine biosynthesisREACTOMER-HSA-500753
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10810pemetrexedChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD11937185, 12651279, 12972956, 14522928, 14647408, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948, 25246386
PA128406956fluorouracilChemicalClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD10561213, 10652619, 11102983, 11142426, 11251009, 11913730, 11937185, 11989786, 15115918, 15353299, 16130010, 16267625, 16575011, 16787927, 7577041, 7586009, 7989939, 10373329, 10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 17549067, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21487324, 21919605, 23263912, 25524944, 25677447, 26189437, 27001118, 27557140, 27864592, 27995989
PA131285527oxaliplatinChemicalVariantAnnotationambiguousPD20385995, 20819423
PA131625240raltitrexedChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD11937185, 12651279, 12972956, 14522928, 14647408, 15353299, 15797993, 16130010, 16456808, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948
PA150595617platinumChemicalVariantAnnotationassociatedPD25677447
PA151917012dactinomycinChemicalVariantAnnotationnot associatedPD19159907
PA164713220Pyrimidine analoguesChemicalClinicalAnnotationassociatedPKPD10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA164777036hydroxychloroquineChemicalVariantAnnotationassociatedPD18322994
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD16501586, 17410198, 27992285
PA165966294Palmar-plantar erythrodysaesthesia syndromeDiseaseVariantAnnotationassociatedPD
PA166114377hand-foot syndromeDiseaseVariantAnnotationnot associatedPD21325291
PA166123026progression-free survivalDiseaseVariantAnnotationassociatedPD25677447
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD29205204
PA166123366event-free survivalDiseaseVariantAnnotationnot associatedPD27864592
PA166153403gastroesophageal cancerDiseaseVariantAnnotationassociatedPD25677447
PA166155331rs45445694VariantLabelAnnotation, VipGeneassociated10652619, 11102983, 11251009, 11913730, 11937185, 11989786, 7586009, 10373329
PA166180936rs11280056VariantVipGeneassociated15115918, 16130010, 16575011, 16787927, 11142426
PA443265AdenocarcinomaDiseaseVariantAnnotationassociatedPD16818689
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD11937185, 12651279, 12972956, 14522928, 14647408, 15457444, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 19902562, 20386493, 21262916, 22838948
PA443448AstheniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD16456808, 28347776
PA443560Breast NeoplasmsDiseaseVariantAnnotationnot associatedPD20638924
PA443622Carcinoma, Non-Small-Cell LungDiseaseVariantAnnotationnot associatedPD18538445, 21605004
PA443756Colonic NeoplasmsDiseaseVariantAnnotationnot associatedPD20665215
PA443899DiarrheaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD28347776
PA443937Drug ToxicityDiseaseClinicalAnnotation, VariantAnnotationambiguousPD16501586, 16818689, 17323057, 17410198, 20638924, 20647221, 20819423, 22838948, 27864592, 27992285
PA444101Esophageal NeoplasmsDiseaseVariantAnnotationambiguousPD
PA444257Gastrointestinal NeoplasmsDiseaseVariantAnnotationnot associatedPD27864592
PA444937MesotheliomaDiseaseClinicalAnnotation, VariantAnnotationambiguousPD21262916, 25246386
PA445013Myelodysplastic SyndromesDiseaseVariantAnnotationassociatedPD29205204
PA445048NauseaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD28347776
PA445062NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD10652619, 11913730, 11937185, 12651279, 12782596, 12972956, 14522928, 14647408, 15797993, 15918040, 16130010, 16182121, 16249645, 16818689, 17203168, 17323057, 17410198, 17549067, 18322994, 18368069, 19159907, 20165956, 20385995, 20386493, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21262916, 21273624, 21325291, 21362378, 21919605, 22838948, 23263912, 25677447, 26189437, 27001118, 27557140, 27864592, 27995989, 28347776
PA445113NeutropeniaDiseaseVariantAnnotationassociatedPD26332308
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21487324, 21919605, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA445451PsoriasisDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD11937185, 12651279, 12972956, 14522928, 14647408, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948
PA445503Rectal NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA445601OsteosarcomaDiseaseVariantAnnotationnot associatedPD19159907
PA445742Stomach NeoplasmsDiseaseVariantAnnotationambiguousPD16249645, 20714149, 23263912
PA445746StomatitisDiseaseVariantAnnotationassociatedPD23652803
PA446051VomitingDiseaseClinicalAnnotation, VariantAnnotationassociatedPD28347776
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD10652619, 11913730, 11937185, 12651279, 12782596, 12972956, 14522928, 14647408, 15797993, 15918040, 16130010, 16182121, 16249645, 16456808, 16818689, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20165956, 20385995, 20386493, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21262916, 21273624, 21325291, 21362378, 21919605, 22838948, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA446116Inflammatory Bowel DiseasesDiseaseVariantAnnotationassociatedPD26332308
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD11937185, 12651279, 12972956, 14522928, 14647408, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948, 23652803
PA447146HyperammonemiaDiseaseVariantAnnotationassociatedPD20714149
PA448492asparaginaseChemicalVariantAnnotationassociatedPD
PA448515azathioprineChemicalVariantAnnotationassociatedPD26332308
PA448771capecitabineChemicalClinicalAnnotation, DataAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD10652619, 11913730, 12782596, 14522928, 15353299, 15918040, 16182121, 16249645, 16818689, 17203168, 17549067, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 26189437, 27001118, 27296624, 27557140, 27864592, 27995989, 28347776
PA448803carboplatinChemicalVariantAnnotationnot associatedPD21262916, 21605004
PA449014cisplatinChemicalVariantAnnotationambiguousPD16249645, 19159907, 21605004
PA449165cyclophosphamideChemicalVariantAnnotationnot associatedPD19159907, 20638924
PA449177cytarabineChemicalVariantAnnotationassociatedPD
PA449212daunorubicinChemicalVariantAnnotationassociatedPD
PA449247dexamethasoneChemicalVariantAnnotationassociatedPD
PA449383docetaxelChemicalVariantAnnotationnot associatedPD21605004
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD19159907
PA449552etoposideChemicalVariantAnnotationassociatedPD
PA449692folic acidChemicalVariantAnnotationassociatedPD18322994
PA449748gemcitabineChemicalVariantAnnotation, VipGeneambiguousPD15655942, 18538445, 21605004
PA450085irinotecanChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD16456808, 21273624
PA450198leucovorinChemicalVariantAnnotationambiguousPKPD16818689, 20385995, 20647221, 20819423, 21273624
PA450379mercaptopurineChemicalVariantAnnotationambiguousPD17323057, 22838948
PA450428methotrexateChemicalClinicalAnnotation, VariantAnnotation, VipGeneambiguousPKPD10652619, 11102983, 11142426, 11251009, 11913730, 11937185, 11989786, 15115918, 16130010, 16207145, 16575011, 16787927, 7586009, 10373329, 11937185, 12651279, 12972956, 14522928, 14647408, 15457444, 15797993, 16130010, 16501586, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 19902562, 20386493, 21262916, 22838948, 23652803, 27992285
PA450761paclitaxelChemicalVariantAnnotationnot associatedPD21605004, 23263912
PA451100prednisoneChemicalVariantAnnotationassociatedPD
PA451547sulfasalazineChemicalVariantAnnotationassociatedPD18322994
PA451879vincristineChemicalVariantAnnotationambiguousPD19159907
PA451881vinorelbineChemicalVariantAnnotationnot associatedPD21605004
PA451996azacitidineChemicalVariantAnnotationassociatedPD29205204
PA452620tegafurChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 26189437, 27001118, 27557140, 27864592, 27995989

References

Pubmed IDYearTitleCitations
361379462023DPYD and TYMS polymorphisms as predictors of 5 fluorouracil toxicity in colorectal cancer patients.1
367896462023Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population.0
371061262023TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background.4
376287692023Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease.1
361379462023DPYD and TYMS polymorphisms as predictors of 5 fluorouracil toxicity in colorectal cancer patients.1
367896462023Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population.0
371061262023TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background.4
376287692023Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease.1
342972382022Association of MTHFR and TYMS gene polymorphisms with the susceptibility to HCC in Egyptian HCV cirrhotic patients.1
346512932022Significance of microRNA-330-5p/TYMS Expression Axis in the Pathogenesis of Colorectal Tumorigenesis.1
358804382022Investigation of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil related toxicities in colorectal cancer.1
359310512022Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita.5
361726602022Evaluation of TS and ENOSF1 Variants as a Biomarker in Response to Neoadjuvant Chemotherapy based on 5FU in Gastric Cancer Patients.3
342972382022Association of MTHFR and TYMS gene polymorphisms with the susceptibility to HCC in Egyptian HCV cirrhotic patients.1
346512932022Significance of microRNA-330-5p/TYMS Expression Axis in the Pathogenesis of Colorectal Tumorigenesis.1

Citation

Dessen P

TYMS (thymidylate synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42737/tyms