UBC (ubiquitin C)

2003-08-01 Affiliation

Identity

HGNC

UBC

LOCATION

12q24.31

LOCUSID

7316

ALIAS

HMG20

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7316
MIM: 191340
HGNC: 12468
Ensembl: ENSG00000150991

Variants:

dbSNP: 7316
ClinVar: 7316
TCGA: ENSG00000150991
COSMIC: UBC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000150991	ENST00000339647	P0CG48
ENSG00000150991	ENST00000535131	F5H265
ENSG00000150991	ENST00000535859	F5H6Q2
ENSG00000150991	ENST00000536769	P0CG48
ENSG00000150991	ENST00000538617	Q96C32
ENSG00000150991	ENST00000540351	F5H747
ENSG00000150991	ENST00000540700	F5GYU3
ENSG00000150991	ENST00000541272	F5GXK7
ENSG00000150991	ENST00000541645	F5H388
ENSG00000150991	ENST00000542416	F5GZ39
ENSG00000150991	ENST00000546120	Q5PY61
ENSG00000150991	ENST00000546271	F5H2Z3

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
PPAR signaling pathway	KEGG	hsa03320
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	REACTOME	R-HSA-532668
Calnexin/calreticulin cycle	REACTOME	R-HSA-901042
ER Quality Control Compartment (ERQC)	REACTOME	R-HSA-901032
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by EGFR in Cancer	REACTOME	R-HSA-1643713
Signaling by Ligand-Responsive EGFR Variants in Cancer	REACTOME	R-HSA-5637815
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	REACTOME	R-HSA-1236382
Signaling by NOTCH1 in Cancer	REACTOME	R-HSA-2644603
Signaling by NOTCH1 HD Domain Mutants in Cancer	REACTOME	R-HSA-2691230
Constitutive Signaling by NOTCH1 HD Domain Mutants	REACTOME	R-HSA-2691232
Signaling by NOTCH1 PEST Domain Mutants in Cancer	REACTOME	R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants	REACTOME	R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	REACTOME	R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	REACTOME	R-HSA-2894862
Hh mutants abrogate ligand secretion	REACTOME	R-HSA-5387390
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	REACTOME	R-HSA-5362768
Disorders of transmembrane transporters	REACTOME	R-HSA-5619115
ABC transporter disorders	REACTOME	R-HSA-5619084
Defective CFTR causes cystic fibrosis	REACTOME	R-HSA-5678895
Diseases of metabolism	REACTOME	R-HSA-5668914
Diseases of carbohydrate metabolism	REACTOME	R-HSA-5663084
Glycogen storage diseases	REACTOME	R-HSA-3229121
Myoclonic epilepsy of Lafora	REACTOME	R-HSA-3785653
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Assembly Of The HIV Virion	REACTOME	R-HSA-175474
Synthesis And Processing Of GAG, GAGPOL Polyproteins	REACTOME	R-HSA-174495
Membrane binding and targetting of GAG proteins	REACTOME	R-HSA-174490
Budding and maturation of HIV virion	REACTOME	R-HSA-162588
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Vif-mediated degradation of APOBEC3G	REACTOME	R-HSA-180585
Vpu mediated degradation of CD4	REACTOME	R-HSA-180534
Amyloid fiber formation	REACTOME	R-HSA-977225
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of NF-kappaB in B cells	REACTOME	R-HSA-1169091
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
IRAK2 mediated activation of TAK1 complex	REACTOME	R-HSA-937042
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	REACTOME	R-HSA-936964
IKK complex recruitment mediated by RIP1	REACTOME	R-HSA-937041
TRAF6 mediated induction of TAK1 complex	REACTOME	R-HSA-937072
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	REACTOME	R-HSA-975163
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
Regulation of innate immune responses to cytosolic DNA	REACTOME	R-HSA-3134975
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Negative regulation of MAPK pathway	REACTOME	R-HSA-5675221
Regulation of RAS by GAPs	REACTOME	R-HSA-5658442
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signaling	REACTOME	R-HSA-5607761
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
NIK-->noncanonical NF-kB signaling	REACTOME	R-HSA-5676590
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
EGFR downregulation	REACTOME	R-HSA-182971
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
Negative regulation of FGFR1 signaling	REACTOME	R-HSA-5654726
Spry regulation of FGF signaling	REACTOME	R-HSA-1295596
Signaling by FGFR2	REACTOME	R-HSA-5654738
Negative regulation of FGFR2 signaling	REACTOME	R-HSA-5654727
Signaling by FGFR3	REACTOME	R-HSA-5654741
Negative regulation of FGFR3 signaling	REACTOME	R-HSA-5654732
Signaling by FGFR4	REACTOME	R-HSA-5654743
Negative regulation of FGFR4 signaling	REACTOME	R-HSA-5654733
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRIF signals cell death from the nucleus	REACTOME	R-HSA-205043
p75NTR signals via NF-kB	REACTOME	R-HSA-193639
p75NTR recruits signalling complexes	REACTOME	R-HSA-209543
NF-kB is activated and signals survival	REACTOME	R-HSA-209560
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB2	REACTOME	R-HSA-1227986
Downregulation of ERBB2:ERBB3 signaling	REACTOME	R-HSA-1358803
Signaling by ERBB4	REACTOME	R-HSA-1236394
Downregulation of ERBB4 signaling	REACTOME	R-HSA-1253288
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling activates SMADs	REACTOME	R-HSA-2173789
Downregulation of TGF-beta receptor signaling	REACTOME	R-HSA-2173788
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	REACTOME	R-HSA-2173791
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Downregulation of SMAD2/3:SMAD4 transcriptional activity	REACTOME	R-HSA-2173795
Signaling by NOTCH	REACTOME	R-HSA-157118
Signaling by NOTCH1	REACTOME	R-HSA-1980143
Activated NOTCH1 Transmits Signal to the Nucleus	REACTOME	R-HSA-2122948
NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	R-HSA-2122947
Signaling by NOTCH2	REACTOME	R-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the Nucleus	REACTOME	R-HSA-2979096
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Wnt	REACTOME	R-HSA-195721
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Deactivation of the beta-catenin transactivating complex	REACTOME	R-HSA-3769402
Degradation of DVL	REACTOME	R-HSA-4641258
Degradation of AXIN	REACTOME	R-HSA-4641257
Regulation of FZD by ubiquitination	REACTOME	R-HSA-4641263
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
Asymmetric localization of PCP proteins	REACTOME	R-HSA-4608870
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog ligand biogenesis	REACTOME	R-HSA-5358346
Hedgehog 'off' state	REACTOME	R-HSA-5610787
GLI3 is processed to GLI3R by the proteasome	REACTOME	R-HSA-5610785
Degradation of GLI2 by the proteasome	REACTOME	R-HSA-5610783
Degradation of GLI1 by the proteasome	REACTOME	R-HSA-5610780
Hedgehog 'on' state	REACTOME	R-HSA-5632684
Death Receptor Signalling	REACTOME	R-HSA-73887
TNF signaling	REACTOME	R-HSA-75893
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
G1/S DNA Damage Checkpoints	REACTOME	R-HSA-69615
p53-Dependent G1/S DNA damage checkpoint	REACTOME	R-HSA-69580
p53-Dependent G1 DNA Damage Response	REACTOME	R-HSA-69563
Stabilization of p53	REACTOME	R-HSA-69541
Autodegradation of the E3 ubiquitin ligase COP1	REACTOME	R-HSA-349425
p53-Independent G1/S DNA damage checkpoint	REACTOME	R-HSA-69613
p53-Independent DNA Damage Response	REACTOME	R-HSA-69610
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	REACTOME	R-HSA-69601
G2/M Checkpoints	REACTOME	R-HSA-69481
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1 Phase	REACTOME	R-HSA-69236
Cyclin D associated events in G1	REACTOME	R-HSA-69231
G1/S Transition	REACTOME	R-HSA-69206
Cyclin E associated events during G1/S transition	REACTOME	R-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21	REACTOME	R-HSA-187577
S Phase	REACTOME	R-HSA-69242
Cyclin A:Cdk2-associated events at S phase entry	REACTOME	R-HSA-69656
Synthesis of DNA	REACTOME	R-HSA-69239
Switching of origins to a post-replicative state	REACTOME	R-HSA-69052
Orc1 removal from chromatin	REACTOME	R-HSA-68949
CDK-mediated phosphorylation and removal of Cdc6	REACTOME	R-HSA-69017
Ubiquitin-dependent degradation of Cyclin D	REACTOME	R-HSA-75815
Ubiquitin-dependent degradation of Cyclin D1	REACTOME	R-HSA-69229
Regulation of DNA replication	REACTOME	R-HSA-69304
Association of licensing factors with the pre-replicative complex	REACTOME	R-HSA-69298
Removal of licensing factors from origins	REACTOME	R-HSA-69300
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
M Phase	REACTOME	R-HSA-68886
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
M/G1 Transition	REACTOME	R-HSA-68874
DNA Replication Pre-Initiation	REACTOME	R-HSA-69002
Assembly of the pre-replicative complex	REACTOME	R-HSA-68867
CDT1 association with the CDC6:ORC:origin complex	REACTOME	R-HSA-68827
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Regulation of APC/C activators between G1/S and early anaphase	REACTOME	R-HSA-176408
SCF-beta-TrCP mediated degradation of Emi1	REACTOME	R-HSA-174113
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176814
APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	REACTOME	R-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	REACTOME	R-HSA-174184
APC-Cdc20 mediated degradation of Nek2A	REACTOME	R-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin B	REACTOME	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	REACTOME	R-HSA-174154
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	REACTOME	R-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/C	REACTOME	R-HSA-174084
Circadian Clock	REACTOME	R-HSA-400253
DNA Replication	REACTOME	R-HSA-69306
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)	REACTOME	R-HSA-917729
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556
Ion channel transport	REACTOME	R-HSA-983712
Stimuli-sensing channels	REACTOME	R-HSA-2672351
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glucose metabolism	REACTOME	R-HSA-70326
Glycogen synthesis	REACTOME	R-HSA-3322077
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Regulation of Apoptosis	REACTOME	R-HSA-169911
Regulation of activated PAK-2p34 by proteasome mediated degradation	REACTOME	R-HSA-211733
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
DNA Repair	REACTOME	R-HSA-73894
DNA Damage Bypass	REACTOME	R-HSA-73893
Recognition of DNA damage by PCNA-containing replication complex	REACTOME	R-HSA-110314
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	REACTOME	R-HSA-110313
Translesion synthesis by REV1	REACTOME	R-HSA-110312
Translesion Synthesis by POLH	REACTOME	R-HSA-110320
Translesion synthesis by POLK	REACTOME	R-HSA-5655862
Translesion synthesis by POLI	REACTOME	R-HSA-5656121
Termination of translesion DNA synthesis	REACTOME	R-HSA-5656169
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
Cellular Senescence	REACTOME	R-HSA-2559583
Oncogene Induced Senescence	REACTOME	R-HSA-2559585
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)	REACTOME	R-HSA-2559582
Regulation of TNFR1 signaling	REACTOME	R-HSA-5357905
DNA Double-Strand Break Repair	REACTOME	R-HSA-5693532
DNA Double Strand Break Response	REACTOME	R-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	REACTOME	R-HSA-5693565
Homology Directed Repair	REACTOME	R-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	REACTOME	R-HSA-5693567
Processing of DNA double-strand break ends	REACTOME	R-HSA-5693607
HDR through Homologous Recombination (HRR)	REACTOME	R-HSA-5685942
Nucleotide Excision Repair	REACTOME	R-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)	REACTOME	R-HSA-5696399
DNA Damage Recognition in GG-NER	REACTOME	R-HSA-5696394
Formation of Incision Complex in GG-NER	REACTOME	R-HSA-5696395
Dual Incision in GG-NER	REACTOME	R-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NER	REACTOME	R-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	REACTOME	R-HSA-6781827
Formation of TC-NER Pre-Incision Complex	REACTOME	R-HSA-6781823
Dual incision in TC-NER	REACTOME	R-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NER	REACTOME	R-HSA-6782210
Fanconi Anemia Pathway	REACTOME	R-HSA-6783310
MAP3K8 (TPL2)-dependent MAPK1/3 activation	REACTOME	R-HSA-5684264
Mitophagy	REACTOME	R-HSA-5205647
Pink/Parkin Mediated Mitophagy	REACTOME	R-HSA-5205685
The role of GTSE1 in G2/M progression after G2 checkpoint	REACTOME	R-HSA-8852276
Signaling by PTK6	REACTOME	R-HSA-8848021
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	REACTOME	R-HSA-8849469
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Regulation of TP53 Activity through Methylation	REACTOME	R-HSA-6804760
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825
Deubiquitination	REACTOME	R-HSA-5688426
UCH proteinases	REACTOME	R-HSA-5689603
Ub-specific processing proteases	REACTOME	R-HSA-5689880
Ovarian tumor domain proteases	REACTOME	R-HSA-5689896
Josephin domain DUBs	REACTOME	R-HSA-5689877
Metalloprotease DUBs	REACTOME	R-HSA-5689901
RET signaling	REACTOME	R-HSA-8853659
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795
Signaling by MET	REACTOME	R-HSA-6806834
Negative regulation of MET activity	REACTOME	R-HSA-6807004
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	REACTOME	R-HSA-8854050
Protein ubiquitination	REACTOME	R-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	REACTOME	R-HSA-8866652
Listeria monocytogenes entry into host cells	REACTOME	R-HSA-8876384
InlA-mediated entry of Listeria monocytogenes into host cells	REACTOME	R-HSA-8876493
InlB-mediated entry of Listeria monocytogenes into host cell	REACTOME	R-HSA-8875360
E3 ubiquitin ligases ubiquitinate target proteins	REACTOME	R-HSA-8866654

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34642328	2021	Structural and functional consequences of NEDD8 phosphorylation.	9
34642328	2021	Structural and functional consequences of NEDD8 phosphorylation.	9
32705536	2020	Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation.	3
32751694	2020	The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells.	12
32887381	2020	Ubiquitin, Autophagy and Neurodegenerative Diseases.	32
32887506	2020	The Roles of Ubiquitin in Mediating Autophagy.	47
32964822	2020	Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease.	5
32705536	2020	Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation.	3
32751694	2020	The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells.	12
32887381	2020	Ubiquitin, Autophagy and Neurodegenerative Diseases.	32
32887506	2020	The Roles of Ubiquitin in Mediating Autophagy.	47
32964822	2020	Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease.	5
31114135	2019	Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3.	2
31811203	2019	A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription.	10
31114135	2019	Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3.	2

Citation

Dessen P

UBC (ubiquitin C)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42743