UBE2V2 (ubiquitin conjugating enzyme E2 V2)

2003-05-01  

Identity

HGNC
UBE2V2
LOCATION
8q11.21
LOCUSID
7336
ALIAS
DDVIT1,DDVit-1,EDAF-1,EDPF-1,EDPF1,MMS2,UEV-2,UEV2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7336
MIM: 603001
HGNC: 12495
Ensembl: ENSG00000169139

Variants:

dbSNP: 7336
ClinVar: 7336
TCGA: ENSG00000169139
COSMIC: UBE2V2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169139ENST00000517630G3V113
ENSG00000169139ENST00000518360H0YBX6
ENSG00000169139ENST00000520595E5RIF1
ENSG00000169139ENST00000520809G3V113
ENSG00000169139ENST00000521346G3V113
ENSG00000169139ENST00000523111Q15819
ENSG00000169139ENST00000523111A0M8W4
ENSG00000169139ENST00000523432H0YBP9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395

References

Pubmed IDYearTitleCitations
377551282023UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.1
377551282023UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.1
337341072021UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.4
337341072021UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.4
322652762020Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.8
326592642020Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.0
322652762020Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.8
326592642020Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.0
259104252015Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.5
261480492015Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.62
259104252015Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.5
261480492015Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.62
248469792014[Roles of hMMS2 gene in reversing the oxaliplatin tolerance of human colon carcinoma cells].3
248469792014[Roles of hMMS2 gene in reversing the oxaliplatin tolerance of human colon carcinoma cells].3
225895452012Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.43

Citation

Dessen P

UBE2V2 (ubiquitin conjugating enzyme E2 V2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42755/ube2v2