UBE4B (ubiquitination factor E4B)

2003-11-01  

Identity

HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
E4,HDNB1,UBOX3,UFD2,UFD2A
FUSION GENES

Other Information

Locus ID:

NCBI: 10277
MIM: 613565
HGNC: 12500
Ensembl: ENSG00000130939

Variants:

dbSNP: 10277
ClinVar: 10277
TCGA: ENSG00000130939
COSMIC: UBE4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130939ENST00000253251O95155
ENSG00000130939ENST00000343090O95155
ENSG00000130939ENST00000377153B1AQ61
ENSG00000130939ENST00000470736K7EP75
ENSG00000130939ENST00000488228K7ERA7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382115302024UBE4B regulates p27 expression in A549 NSCLC cells through regulating the interaction of HuR and the p27 5' UTR.0
382115302024UBE4B regulates p27 expression in A549 NSCLC cells through regulating the interaction of HuR and the p27 5' UTR.0
372640222023A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling.2
379571382023UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis.0
372640222023A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling.2
379571382023UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis.0
352201702022UBE4B promotes the development of lung adenocarcinoma by enhancing proliferation, migration and glycolysis via PP2A/AKT signaling.2
364706692022Upregulated UBE4B expression correlates with poor prognosis and tumor immune infiltration in hepatocellular carcinoma.2
352201702022UBE4B promotes the development of lung adenocarcinoma by enhancing proliferation, migration and glycolysis via PP2A/AKT signaling.2
364706692022Upregulated UBE4B expression correlates with poor prognosis and tumor immune infiltration in hepatocellular carcinoma.2
340789052021UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.24
340789052021UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.24
314758822019Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition.7
314758822019Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition.7
293269752018Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.29

Citation

Dessen P

UBE4B (ubiquitination factor E4B)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42757/haematological-explorer/css/lib/js/_common.js