UCHL1 (ubiquitin C-terminal hydrolase L1)

2004-04-01  

Identity

HGNC
UCHL1
LOCATION
4p13
LOCUSID
7345
ALIAS
HEL-117,HEL-S-53,NDGOA,PARK5,PGP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7345
MIM: 191342
HGNC: 12513
Ensembl: ENSG00000154277

Variants:

dbSNP: 7345
ClinVar: 7345
TCGA: ENSG00000154277
COSMIC: UCHL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154277ENST00000284440P09936
ENSG00000154277ENST00000284440V9HW74
ENSG00000154277ENST00000503431P09936
ENSG00000154277ENST00000503431V9HW74
ENSG00000154277ENST00000505232D6R974
ENSG00000154277ENST00000508768D6RE83
ENSG00000154277ENST00000512419D6RJD9
ENSG00000154277ENST00000512788D6R956
ENSG00000154277ENST00000514924D6RF53

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361289172024Changes in Serum LncRNA MEG3/miR-181b and UCH-L1 Levels in Patients with Moderate and Severe Intracerebral Hemorrhage.1
381316672024Digenic FLNA and UCHL1 variants resulting in a complex phenotype.0
382445402024UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas.3
382793022024Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease.1
386691402024Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia.1
361289172024Changes in Serum LncRNA MEG3/miR-181b and UCH-L1 Levels in Patients with Moderate and Severe Intracerebral Hemorrhage.1
381316672024Digenic FLNA and UCHL1 variants resulting in a complex phenotype.0
382445402024UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas.3
382793022024Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson's Disease.1
386691402024Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia.1
361630882023Ubiquitin C-terminal hydrolase 1 is increased in migraine attack.0
366812492023Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury.11
368305632023Pivotal Role of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) in Uterine Leiomyoma.1
370235262023Associations of blood UCH-L1 and NfL levels with cognitive dysfunction in Parkinson's disease patients.0
371189212023Ubiquitin C-terminal hydrolase L1 after out-of-hospital cardiac arrest.1

Citation

Dessen P

UCHL1 (ubiquitin C-terminal hydrolase L1)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/42761