UGCG (UDP-glucose ceramide glucosyltransferase)

2003-08-01  

Identity

HGNC
LOCATION
9q31.3
LOCUSID
ALIAS
GCS,GLCT1
FUSION GENES

Other Information

Locus ID:

NCBI: 7357
MIM: 602874
HGNC: 12524
Ensembl: ENSG00000148154

Variants:

dbSNP: 7357
ClinVar: 7357
TCGA: ENSG00000148154
COSMIC: UGCG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148154ENST00000374279Q16739
ENSG00000148154ENST00000374279A0A024R157

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Lactosylceramide biosynthesisKEGGhsa_M00066
Lactosylceramide biosynthesisKEGGM00066
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384996192024Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.0
385421932024Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.0
384996192024Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.0
385421932024Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.0
370048772023Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.1
370048772023Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.1
351680602022Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.5
351680602022Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.5
329805362021Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide.1
336841452021β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model.7
346865082021UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway.6
329805362021Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide.1
336841452021β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model.7
346865082021UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway.6
324242632020UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells.16

Citation

Dessen P

UGCG (UDP-glucose ceramide glucosyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42763/favicon/js/deep-insight-explorer/