UHRF2 (ubiquitin like with PHD and ring finger domains 2)

2003-06-01  

Identity

HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
NIRF,RNF107,TDRD23,URF2
FUSION GENES

Other Information

Locus ID:

NCBI: 115426
MIM: 615211
HGNC: 12557
Ensembl: ENSG00000147854

Variants:

dbSNP: 115426
ClinVar: 115426
TCGA: ENSG00000147854
COSMIC: UHRF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147854ENST00000276893Q96PU4
ENSG00000147854ENST00000381373B1AL33
ENSG00000147854ENST00000450508A0A0A0MSQ3
ENSG00000147854ENST00000468435Q96PU4

Expression (GTEx)

0
5
10
15
20
25
30
35

References

Pubmed IDYearTitleCitations
348260272022MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.8
348260272022MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.8
338483952021UV-induced activation of ATR is mediated by UHRF2.2
338763952021HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2.3
341113982021UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.12
341625622021IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the Proliferation of and Inhibit the Apoptosis of Esophageal Squamous Cell Carcinoma.6
344008802021UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating ErbB3/Ras/Raf Signaling Pathway.6
338483952021UV-induced activation of ATR is mediated by UHRF2.2
338763952021HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2.3
341113982021UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.12
341625622021IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the Proliferation of and Inhibit the Apoptosis of Esophageal Squamous Cell Carcinoma.6
344008802021UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating ErbB3/Ras/Raf Signaling Pathway.6
323724482020UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.13
323724482020UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.13
295061312018Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.18

Citation

Dessen P

UHRF2 (ubiquitin like with PHD and ring finger domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42765/cancer-prone-explorer/tumors-explorer/deep-insight-explorer/