UNG (uracil DNA glycosylase)

2003-02-01  

Identity

HGNC
UNG
LOCATION
12q24.11
LOCUSID
7374
ALIAS
DGU,HIGM4,HIGM5,UDG,UNG1,UNG15,UNG2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7374
MIM: 191525
HGNC: 12572
Ensembl: ENSG00000076248

Variants:

dbSNP: 7374
ClinVar: 7374
TCGA: ENSG00000076248
COSMIC: UNG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076248ENST00000242576P13051
ENSG00000076248ENST00000242576E5KTA5
ENSG00000076248ENST00000336865P13051
ENSG00000076248ENST00000336865E5KTA6
ENSG00000076248ENST00000446767Q68DM5
ENSG00000076248ENST00000539287F5GYA2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Primary immunodeficiencyKEGGko05340
Base excision repairKEGGhsa03410
Primary immunodeficiencyKEGGhsa05340
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368838842023Replication Protein A Enhances Kinetics of Uracil DNA Glycosylase on ssDNA and Across DNA Junctions: Explored with a DNA Repair Complex Produced with SpyCatcher/SpyTag Ligation.0
368902762023Uracil-DNA glycosylase efficiency is modulated by substrate rigidity.0
368838842023Replication Protein A Enhances Kinetics of Uracil DNA Glycosylase on ssDNA and Across DNA Junctions: Explored with a DNA Repair Complex Produced with SpyCatcher/SpyTag Ligation.0
368902762023Uracil-DNA glycosylase efficiency is modulated by substrate rigidity.0
336407582021The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions.4
348196702021FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.19
336407582021The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions.4
348196702021FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.19
318558462020Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2.5
329982462020Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins.3
318558462020Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2.5
329982462020Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins.3
307474912019A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers.0
308384092019Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.14
313185482019QM/MM Study of the Uracil DNA Glycosylase Reaction Mechanism: A Competition between Asp145 and His148.2

Citation

Dessen P

UNG (uracil DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42767