USP8 (ubiquitin specific peptidase 8)

2003-02-01  

Identity

HGNC
USP8
LOCATION
15q21.2
LOCUSID
9101
ALIAS
HumORF8,PITA4,SPG59,UBPY
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9101
MIM: 603158
HGNC: 12631
Ensembl: ENSG00000138592

Variants:

dbSNP: 9101
ClinVar: 9101
TCGA: ENSG00000138592
COSMIC: USP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138592ENST00000307179P40818
ENSG00000138592ENST00000307179A0A024R5S4
ENSG00000138592ENST00000396444P40818
ENSG00000138592ENST00000396444A0A024R5S4
ENSG00000138592ENST00000425032P40818
ENSG00000138592ENST00000558091H0YNL5
ENSG00000138592ENST00000559242H0YLS3
ENSG00000138592ENST00000559329A0A075B720
ENSG00000138592ENST00000560297H0YLH2
ENSG00000138592ENST00000560730H0YKV1
ENSG00000138592ENST00000560982H0YM17
ENSG00000138592ENST00000561211H0YLS3
ENSG00000138592ENST00000561330H0YM47
ENSG00000138592ENST00000625664H0YLS3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Downregulation of ERBB2:ERBB3 signalingREACTOMER-HSA-1358803
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795
Signaling by METREACTOMER-HSA-6806834
Negative regulation of MET activityREACTOMER-HSA-6807004
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377041592024Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension.0
381804762024USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes.1
386916592024A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours.0
377041592024Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension.0
381804762024USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes.1
386916592024A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours.0
371900522023USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons.0
373320452023piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.7
376397422023USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2.3
377417742023USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane.0
379253202023Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease.2
379815922023Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.0
371900522023USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons.0
373320452023piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination.7
376397422023USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2.3

Citation

Dessen P

USP8 (ubiquitin specific peptidase 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42774