VEGFC (vascular endothelial growth factor C)

2003-02-01  

Identity

HGNC
VEGFC
LOCATION
4q34.3
LOCUSID
7424
ALIAS
Flt4-L,LMPH1D,LMPHM4,VRP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7424
MIM: 601528
HGNC: 12682
Ensembl: ENSG00000150630

Variants:

dbSNP: 7424
ClinVar: 7424
TCGA: ENSG00000150630
COSMIC: VEGFC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150630ENST00000618562P49767

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalPathwayassociated20124951
PA166118342afliberceptChemicalPathwayassociated20124951
PA28180FLT1GenePathwayassociated20124951
PA30086KDRGenePathwayassociated20124951
PA31783NRP1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
379427012024Association of plasma NRP2 and VEGF-C levels with prostate cancer disease severity.0
380921442024Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma.0
380921602024Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty.0
382116482024DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion.0
383721162024Comparative study on the expression of Pax3, Rad51 and VEGF-C in esophageal gastric junction adenocarcinoma and distal gastric adenocarcinoma.0
387289432024miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.0
379427012024Association of plasma NRP2 and VEGF-C levels with prostate cancer disease severity.0
380921442024Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma.0
380921602024Correlation of serum VEGF-C, ANGPTL4, and activin A levels with frailty.0
382116482024DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion.0
383721162024Comparative study on the expression of Pax3, Rad51 and VEGF-C in esophageal gastric junction adenocarcinoma and distal gastric adenocarcinoma.0
387289432024miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.0
366177352023CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.1
366825772023Diagnostic and prognostic value of plasma cell-free DNA combined with VEGF-C in laryngeal squamous cell carcinoma.4
367667252023Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells.0

Citation

Dessen P

VEGFC (vascular endothelial growth factor C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42789/cancer-prone-explorer/img/gene-fusions/?id=42789