WISP2 (Wnt-1-inducible signaling parthway protein-2)

2004-12-01   Sushanta K. Banerjee  , Snigdha Banerjee  

Division of Hematology\\\/Oncology, Depatment of Medicine,, Department of Anatomy, Cell Biology University of Kansas Medical Center, Research Director, Cancer Research Unit, VA Medical Center, Kansas City, MO 64128, USA

Identity

HGNC
WISP2
LOCATION
20q13.12
LOCUSID
8839
ALIAS
CT58,CTGF-L,WISP2
FUSION GENES
Show Gene Fusions

DNA/RNA

Note

Until now, three genes have been identified and isolated as members of WISP sub-family. WISP-1/CCN4, WISP-2/CCN5 and WISP-3/CCN6 genes were localized in human chromosomes 8q24.1-q24.3, 20q12-q13 and 6q22-23, respectively and exhibit tissue specific patterns of expression. Nucleotide and protein sequence alignment studies have demonstrated a 30-40% sequence homology within WISP genes and their modular architecture is similar except in their C-terminal domains, which is absent in the WISP-2 gene.
Atlas Image
Modular structure of individual genes of WISP sub-family of CCN family. Module shown with color boxes are the predicted primary translational.

Proteins

Description

The translation products of most of the CCN family members are secreted proteins of 35-40 kDa and have been shown to contain four distinct structural modules: 1) an IGF-binding protein type (IGFBP) domain, 2) a Von Willebrand type C (VWC) domain; 3) a Thrombospondin-1 (TSP-1) domain and 4) a C-terminal Cysteine-knot (CT) domain (10). Although the functional roles of these multiple modules are unclear, they raise interesting questions as to the contribution of each individual module to the biological properties of the full-length proteins.

Expression

Epithelial cells and vascular smooth muscle cells

Localisation

Adrenal gland, breast, colon, pancreas, uterus and ovary.

Function

Positive regulator of epithelial cells and negative regulator of vascular smooth muscle cells.

Mutations

Somatic

Amplified in breast tumor cells.

Implicated in

Disease
Breast cancer

Article Bibliography

Pubmed IDLast YearTitleAuthors
126596712003WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation.Banerjee S et al
147674692004Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators.Bourdeau I et al
129510452003Estrogen-induced genes, WISP-2 and pS2, respond divergently to protein kinase pathway.Inadera H et al
103580671999Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions.Kumar S et al
149811452004The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells.Mason HR et al
98439551998WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors.Pennica D et al
118557472001Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines.Saxena N et al

Citation

Sushanta K. Banerjee ; Snigdha Banerjee

WISP2 (Wnt-1-inducible signaling parthway protein-2)

Atlas Genet Cytogenet Oncol Haematol. 2004-12-01

Online version: http://atlasgeneticsoncology.org/gene/42814/wisp2-(wnt-1-inducible-signaling-parthway-protein-2)