ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2)

2003-06-01 Affiliation

Identity

HGNC

ZDHHC2

LOCATION

8p22

LOCUSID

51201

ALIAS

DHHC2,ZNF372

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51201
MIM: 618621
HGNC: 18469
Ensembl: ENSG00000104219

Variants:

dbSNP: 51201
ClinVar: 51201
TCGA: ENSG00000104219
COSMIC: ZDHHC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104219	ENST00000262096	Q9UIJ5
ENSG00000104219	ENST00000262096	A0A140VKD9
ENSG00000104219	ENST00000522184	E5RFZ7
ENSG00000104219	ENST00000523132	A0A1Y8EM58

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Surfactant metabolism	REACTOME	R-HSA-5683826

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32180374	2020	Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.	4
33488612	2020	Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.	13
32180374	2020	Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.	4
33488612	2020	Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.	13
24995331	2014	A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma.	15
24995331	2014	A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma.	15
23457560	2013	Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma.	20
23457560	2013	Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma.	20
21343290	2011	Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.	19
21471008	2011	The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.	37
22034844	2011	DHHC2 is a protein S-acyltransferase for Lck.	15
21343290	2011	Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.	19
21471008	2011	The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.	37
22034844	2011	DHHC2 is a protein S-acyltransferase for Lck.	15
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78

Citation

Dessen P

ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42865