PER1 (period circadian regulator 1)

2004-12-01  

Identity

HGNC
PER1
LOCATION
17p13.1
LOCUSID
5187
ALIAS
PER,RIGUI,hPER
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5187
MIM: 602260
HGNC: 8845
Ensembl: ENSG00000179094

Variants:

dbSNP: 5187
ClinVar: 5187
TCGA: ENSG00000179094
COSMIC: PER1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179094ENST00000317276O15534
ENSG00000179094ENST00000577253J3KSL6
ENSG00000179094ENST00000581082J3KRL7
ENSG00000179094ENST00000581395J3QSH9
ENSG00000179094ENST00000581703J3QL55
ENSG00000179094ENST00000582719J3KTM2
ENSG00000179094ENST00000583559J3QL46
ENSG00000179094ENST00000584202J3QLQ5

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

References

Pubmed IDYearTitleCitations
382455102024DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.0
382455102024DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.0
354754972023Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A β-lactamase enzymes.0
354754972023Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A β-lactamase enzymes.0
349216592022Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer's disease and longevity in an Italian population.5
352551182022Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.26
356783172022The biological clock gene PER1 affects the development of oral squamous cell carcinoma by altering the circadian rhythms of cell proliferation and apoptosis.1
359852382022LncRNA TPTEP1 inhibits the migration and invasion of gastric cancer cells through miR-548d-3p/KLF9/PER1 axis.2
349216592022Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer's disease and longevity in an Italian population.5
352551182022Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.26
356783172022The biological clock gene PER1 affects the development of oral squamous cell carcinoma by altering the circadian rhythms of cell proliferation and apoptosis.1
359852382022LncRNA TPTEP1 inhibits the migration and invasion of gastric cancer cells through miR-548d-3p/KLF9/PER1 axis.2
337232212021PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex.24
338041242021The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments.8
344932772021A missense variant rs2585405 in clock gene PER1 is associated with the increased risk of noise-induced hearing loss in a Chinese occupational population.3

Citation

Dessen P

PER1 (period circadian regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-12-01

Online version: http://atlasgeneticsoncology.org/gene/42892