PRRX2 (paired related homeobox 2)
2005-10-01 Carine Gervais AffiliationLaboratoire dHématologie et de Cytogénétique Onco-Hématologique, CHU de Hautepierre, Avenue Moliöre - BP 49, 67098 Strasbourg cedex, France
DNA/RNA
Description
57 kb, 4 exons
Transcription
1327 bp mRNA
Proteins
Note
Paired mesoderm homeobox protein 2, Paired related homeobox protein 2
PRRX2 protein. HD = Homeodomain.
Description
253 amino acids, 27 kDa, contains an homeobox DNA-binding domain and an OAR domain.
Expression
In embryon, higher levels of transcripts in heart, kidney, lung and skeletal muscle; lower levels in spleen and thymus ; barely detecteble levels in brain and liver.
In adult, higher levels in heart, lung, placenta and pancreas ; moderate expression in kidney and skeletal muscle.
In adult, higher levels in heart, lung, placenta and pancreas ; moderate expression in kidney and skeletal muscle.
Localisation
Nuclear
Function
Fetal skin development, cutaneous regeneration and possible role in cellular proliferation. Transcription factor activity.
Homology
Member of the paired family of homeobox proteins.
Murine Prrx2.
Murine Prrx2.
Implicated in
Entity name
Disease
one case of adult t-AML
Cytogenetics
no additional cytogenetic abnormality in this case
Hybrid gene
5 NUP98 3 PRRX2
NUP98-PRRX2 fusion cDNA partial sequence.
Fusion protein
fuses the GLFG repeat domains of NUP98 to the homeodomain of PRRX2
Structure of the predicted chimeric NUP98-PRRX2 protein. FG = Phe-Gly repeats, GLEBS = RAE1 binding domain, HD = homeodomain.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 15496970 | 2005 | A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. | Gervais C et al |
| 11681408 | 2001 | NUP98 gene fusions in hematologic malignancies. | Lam DH et al |
| 10397741 | 1999 | NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). | Nakamura T et al |
| 11063257 | 2000 | Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. | Norris RA et al |
| 9665387 | 1998 | Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. | Stelnicki EJ et al |
| 12535210 | 2003 | Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. | White P et al |
Other Information
Locus ID:
NCBI: 51450
MIM: 604675
HGNC: 21338
Ensembl: ENSG00000167157
Variants:
dbSNP: 51450
ClinVar: 51450
TCGA: ENSG00000167157
COSMIC: PRRX2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000167157 | ENST00000372469 | Q99811 |
| ENSG00000167157 | ENST00000372469 | A0A140VJS2 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36266731 | 2022 | CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. | 35 |
| 36266731 | 2022 | CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. | 35 |
| 32234171 | 2020 | [Effects of Prrx2 gene silencing on the proliferation of breast cancer and its molecular mechanisms]. | 0 |
| 32234171 | 2020 | [Effects of Prrx2 gene silencing on the proliferation of breast cancer and its molecular mechanisms]. | 0 |
| 31255287 | 2019 | Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. | 8 |
| 31471104 | 2019 | Inhibition of PRRX2 suppressed colon cancer liver metastasis via inactivation of Wnt/β-catenin signaling pathway. | 10 |
| 31255287 | 2019 | Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. | 8 |
| 31471104 | 2019 | Inhibition of PRRX2 suppressed colon cancer liver metastasis via inactivation of Wnt/β-catenin signaling pathway. | 10 |
| 26824226 | 2016 | PRRX2 as a novel TGF-β-induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer. | 19 |
| 26824226 | 2016 | PRRX2 as a novel TGF-β-induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer. | 19 |
| 21385867 | 2011 | Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study. | 47 |
| 21385867 | 2011 | Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study. | 47 |
| 20634891 | 2010 | Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. | 28 |
| 20634891 | 2010 | Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. | 28 |
| 17964282 | 2007 | Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. | 5 |
Citation
Carine Gervais
PRRX2 (paired related homeobox 2)
Atlas Genet Cytogenet Oncol Haematol. 2005-10-01
Online version: http://atlasgeneticsoncology.org/gene/42897/prrx2
