PRKD2 (protein kinase D2)

2004-06-01  

Identity

HGNC
PRKD2
LOCATION
19q13.32
LOCUSID
25865
ALIAS
HSPC187,PKD2,nPKC-D2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25865
MIM: 607074
HGNC: 17293
Ensembl: ENSG00000105287

Variants:

dbSNP: 25865
ClinVar: 25865
TCGA: ENSG00000105287
COSMIC: PRKD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105287ENST00000291281Q9BZL6
ENSG00000105287ENST00000433867Q9BZL6
ENSG00000105287ENST00000593363M0R346
ENSG00000105287ENST00000595132M0QZ82
ENSG00000105287ENST00000595515Q9BZL6
ENSG00000105287ENST00000597390M0R2Z8
ENSG00000105287ENST00000597641M0QXC6
ENSG00000105287ENST00000598633M0R012
ENSG00000105287ENST00000600194Q9BZL6
ENSG00000105287ENST00000601605M0QZC2
ENSG00000105287ENST00000601806Q9BZL6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384112802024Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression.0
384112802024Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression.0
360178582023Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway.0
376161632023Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.2
360178582023Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway.0
376161632023Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.2
339491052021Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.8
339491052021Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity.8
306524152019Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.8
307185932019High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition.3
308419312019Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.24
308436212019Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.5
306524152019Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.8
307185932019High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition.3
308419312019Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.24

Citation

Dessen P

PRKD2 (protein kinase D2)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42916/js/js/lib/popper.js