PLIN3 (perilipin 3)

2004-11-01  

Identity

HGNC
PLIN3
LOCATION
19p13.3
LOCUSID
10226
ALIAS
M6PRBP1,PP17,TIP47
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10226
MIM: 602702
HGNC: 16893
Ensembl: ENSG00000105355

Variants:

dbSNP: 10226
ClinVar: 10226
TCGA: ENSG00000105355
COSMIC: PLIN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105355ENST00000221957O60664
ENSG00000105355ENST00000585479O60664
ENSG00000105355ENST00000585479A0A140VJN8
ENSG00000105355ENST00000587462K7EJD0
ENSG00000105355ENST00000589034K7EL96
ENSG00000105355ENST00000589163K7ERZ3
ENSG00000105355ENST00000589494K7ER39
ENSG00000105355ENST00000592528O60664

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382877242024Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression.1
385541522024Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma.0
382877242024Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression.1
385541522024Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma.0
372686302023Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.10
375784652023Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc.0
378983982023Binding of perilipin 3 to membranes containing diacylglycerol is mediated by conserved residues within its PAT domain.1
372686302023Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.10
375784652023Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc.0
378983982023Binding of perilipin 3 to membranes containing diacylglycerol is mediated by conserved residues within its PAT domain.1
351211292022Lipophagy-Related Protein Perilipin-3 and Resistance of Prostate Cancer to Radiation Therapy.6
351211292022Lipophagy-Related Protein Perilipin-3 and Resistance of Prostate Cancer to Radiation Therapy.6
342330242021A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis.16
344105222021Suppressed PLIN3 frequently occurs in prostate cancer, promoting docetaxel resistance via intensified autophagy, an event reversed by chloroquine.5
347650492021Associations of Perilipin 3 with Insulin Resistance in Arab Adults with Type 2 Diabetes.1

Citation

Dessen P

PLIN3 (perilipin 3)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42938/haematological-explorer/css/favicon/apple-touch-icon.png