Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 94015
MIM: 608855
HGNC: 13877
Ensembl: ENSG00000141540
Variants:
dbSNP: 94015
ClinVar: 94015
TCGA: ENSG00000141540
COSMIC: TTYH2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Stimuli-sensing channels | REACTOME | R-HSA-2672351 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34048708 | 2021 | SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. | 89 |
| 34385445 | 2021 | Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. | 10 |
| 34048708 | 2021 | SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. | 89 |
| 34385445 | 2021 | Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. | 10 |
| 30670146 | 2019 | Surface expression of TTYH2 is attenuated by direct interaction with β-COP. | 9 |
| 31230749 | 2019 | Upregulated TTYH2 expression is critical for the invasion and migration of U2OS human osteosarcoma cell lines. | 9 |
| 30670146 | 2019 | Surface expression of TTYH2 is attenuated by direct interaction with β-COP. | 9 |
| 31230749 | 2019 | Upregulated TTYH2 expression is critical for the invasion and migration of U2OS human osteosarcoma cell lines. | 9 |
| 18260827 | 2008 | N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). | 14 |
| 18577513 | 2008 | The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. | 14 |
| 18260827 | 2008 | N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). | 14 |
| 18577513 | 2008 | The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. | 14 |
| 17569141 | 2007 | TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. | 17 |
| 17569141 | 2007 | TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. | 17 |
| 11597145 | 2001 | TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. | 21 |
Citation
Dessen P
TTYH2 (tweety family member 2)
Atlas Genet Cytogenet Oncol Haematol. 2004-11-01
Online version: http://atlasgeneticsoncology.org/gene/42954/ttyh2
