DCPS (decapping enzyme, scavenger)

2006-12-01  

Identity

HGNC
DCPS
LOCATION
11q24.2
LOCUSID
28960
ALIAS
ARS,DCS1,HINT-5,HINT5,HSL1,HSPC015
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 28960
MIM: 610534
HGNC: 29812
Ensembl: ENSG00000110063

Variants:

dbSNP: 28960
ClinVar: 28960
TCGA: ENSG00000110063
COSMIC: DCPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110063ENST00000263579Q96C86
ENSG00000110063ENST00000263579A0A384MTI8
ENSG00000110063ENST00000648516A0A3B3ITF0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 3' to 5' exoribonucleaseREACTOMER-HSA-429958

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
327238152020Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.8
327706502020Leukoencephalopathy in Al-Raqad syndrome: Expanding the clinical and neuroimaging features caused by a biallelic novel missense variant in DCPS.1
327238152020Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme.8
327706502020Leukoencephalopathy in Al-Raqad syndrome: Expanding the clinical and neuroimaging features caused by a biallelic novel missense variant in DCPS.1
257018702015Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.27
257121292015Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.20
260017962015DcpS is a transcript-specific modulator of RNA in mammalian cells.13
262419642015Structure and Function in Homodimeric Enzymes: Simulations of Cooperative and Independent Functional Motions.5
265845882015The human decapping scavenger enzyme DcpS modulates microRNA turnover.9
257018702015Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.27
257121292015Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.20
260017962015DcpS is a transcript-specific modulator of RNA in mammalian cells.13
262419642015Structure and Function in Homodimeric Enzymes: Simulations of Cooperative and Independent Functional Motions.5
265845882015The human decapping scavenger enzyme DcpS modulates microRNA turnover.9
187252662009Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme.10

Citation

Dessen P

DCPS (decapping enzyme, scavenger)

Atlas Genet Cytogenet Oncol Haematol. 2006-12-01

Online version: http://atlasgeneticsoncology.org/gene/42988/css/lib/favicon/meetings/