DMAP1 (DNA methyltransferase 1 associated protein 1)

2007-04-01  

Identity

HGNC
DMAP1
LOCATION
1p34.1
LOCUSID
55929
ALIAS
DNMAP1,DNMTAP1,EAF2,MEAF2,SWC4

Other Information

Locus ID:

NCBI: 55929
MIM: 605077
HGNC: 18291
Ensembl: ENSG00000178028

Variants:

dbSNP: 55929
ClinVar: 55929
TCGA: ENSG00000178028
COSMIC: DMAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178028ENST00000315913Q9NPF5
ENSG00000178028ENST00000361745Q9NPF5
ENSG00000178028ENST00000372289Q9NPF5
ENSG00000178028ENST00000372290Q5TG37
ENSG00000178028ENST00000436069Q5TG36
ENSG00000178028ENST00000437511Q5TG39
ENSG00000178028ENST00000440641Q5TG38
ENSG00000178028ENST00000446292Q5TG40

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
305532762018C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer.7
305532762018C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer.7
262066652016MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.33
262066652016MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.33
233184252014DMAP1 is an essential regulator of ATM activity and function.18
243612152014si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.9
233184252014DMAP1 is an essential regulator of ATM activity and function.18
243612152014si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.9
212840502011Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.7
212840502011Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.7
208645252010DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair.36
209204672010Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression.3
208645252010DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair.36
209204672010Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression.3
147345562004RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.27

Citation

Dessen P

DMAP1 (DNA methyltransferase 1 associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/43045