DMAP1 (DNA methyltransferase 1 associated protein 1)

2007-04-01  

Identity

HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
DNMAP1,DNMTAP1,EAF2,MEAF2,SWC4

Other Information

Locus ID:

NCBI: 55929
MIM: 605077
HGNC: 18291
Ensembl: ENSG00000178028

Variants:

dbSNP: 55929
ClinVar: 55929
TCGA: ENSG00000178028
COSMIC: DMAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178028ENST00000315913Q9NPF5
ENSG00000178028ENST00000361745Q9NPF5
ENSG00000178028ENST00000372289Q9NPF5
ENSG00000178028ENST00000372290Q5TG37
ENSG00000178028ENST00000436069Q5TG36
ENSG00000178028ENST00000437511Q5TG39
ENSG00000178028ENST00000440641Q5TG38
ENSG00000178028ENST00000446292Q5TG40

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208645252010DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair.25
147345562004RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.22
262066652016MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.20
233184252014DMAP1 is an essential regulator of ATM activity and function.11
212840502011Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.6
243612152014si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.6
209204672010Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression.3
305532762018C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer.1

Citation

Dessen P

DMAP1 (DNA methyltransferase 1 associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/43045/dmap1-(dna-methyltransferase-1-associated-protein-1)