S1PR4 (sphingosine-1-phosphate receptor 4)

2011-03-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
EDG6,LPC1,S1P4,SLP4

Other Information

Locus ID:

NCBI: 8698
MIM: 603751
HGNC: 3170
Ensembl: ENSG00000125910

Variants:

dbSNP: 8698
ClinVar: 8698
TCGA: ENSG00000125910
COSMIC: S1PR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125910ENST00000246115O95977

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
FoxO signaling pathwayKEGGhsa04068
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
360683912023Silence of S1PR4 Represses the Activation of Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway.2
360683912023Silence of S1PR4 Represses the Activation of Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway.2
350133822022The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.6
350133822022The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.6
308771432019CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.47
312458692019NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.14
308771432019CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.47
312458692019NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis.14
281484972017Shear stress induces Gα(q/11) activation independently of G protein-coupled receptor activation in endothelial cells.17
282066092017Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis.10
281484972017Shear stress induces Gα(q/11) activation independently of G protein-coupled receptor activation in endothelial cells.17
282066092017Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis.10
267833402016S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.28
273999672016Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits.25
267833402016S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.28

Citation

Dessen P

S1PR4 (sphingosine-1-phosphate receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/43047/s1pr4