CHD1L (chromodomain helicase DNA binding protein 1 like)

2005-11-01   Dessen P  

Identity

HGNC
CHD1L
LOCATION
1q21.1
LOCUSID
9557
ALIAS
ALC1,CHDL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9557
MIM: 613039
HGNC: 1916
Ensembl: ENSG00000131778

Variants:

dbSNP: 9557
ClinVar: 9557
TCGA: ENSG00000131778
COSMIC: CHD1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131778ENST00000361293A0A0A0MRH8
ENSG00000131778ENST00000369258Q86WJ1
ENSG00000131778ENST00000369259Q86WJ1
ENSG00000131778ENST00000431239A0A0A0MSH9
ENSG00000131778ENST00000467213A0A087WTM4
ENSG00000131778ENST00000488864A0A087WZM7
ENSG00000131778ENST00000622533A0A087WWW4
ENSG00000131778ENST00000639534A0A1W2PP16
ENSG00000131778ENST00000650714A0A494C1P7
ENSG00000131778ENST00000650721A0A494C0J6
ENSG00000131778ENST00000650828A0A494C1F3
ENSG00000131778ENST00000651070A0A494C0J6
ENSG00000131778ENST00000651206A0A494C0F0
ENSG00000131778ENST00000651207A0A494C1H1
ENSG00000131778ENST00000651226A0A494C0B8
ENSG00000131778ENST00000651231A0A494C1F7
ENSG00000131778ENST00000651407A0A494C0J6
ENSG00000131778ENST00000651410A0A494C111
ENSG00000131778ENST00000651420A0A494C1S1
ENSG00000131778ENST00000651510A0A494C1I3
ENSG00000131778ENST00000651820A0A494C0M4
ENSG00000131778ENST00000652161A0A494C1S1
ENSG00000131778ENST00000652188A0A494C0Q0
ENSG00000131778ENST00000652278A0A494C1I3
ENSG00000131778ENST00000652346A0A087WZM7
ENSG00000131778ENST00000652357A0A494C1H1
ENSG00000131778ENST00000652486A0A494C1H0
ENSG00000131778ENST00000652494A0A494C1I3
ENSG00000131778ENST00000652587A0A494C179
ENSG00000131778ENST00000652616A0A494C1H1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Dual Incision in GG-NERREACTOMER-HSA-5696400

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377472372023Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.0
377472372023Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.0
350018352022Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.2
350018352022Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.2
334623942021ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells.60
337239412021Effect of chromodomain helicase/ATPase DNA binding protein 1-like gene on the invasion and metastasis of tongue squamous cell carcinoma CAL27 cells.0
337258402021The high expression of CHD1L and its clinical significance in human solid tumors: A meta-analysis.0
338130772021Suppressing CHD1L reduces the proliferation and chemoresistance in osteosarcoma.5
342109772021Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.9
342454282021Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus.3
344656252021Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.3
344865212021Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.14
345884202021CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.3
346547972021CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.12
348742662021Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.13

Citation

Dessen P

CHD1L (chromodomain helicase DNA binding protein 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43051/chd1l