RNASEH2B (ribonuclease H2 subunit B)

2005-11-01  

Identity

HGNC
RNASEH2B
LOCATION
13q14.3
LOCUSID
79621
ALIAS
AGS2,DLEU8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79621
MIM: 610326
HGNC: 25671
Ensembl: ENSG00000136104

Variants:

dbSNP: 79621
ClinVar: 79621
TCGA: ENSG00000136104
COSMIC: RNASEH2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136104ENST00000336617Q5TBB1
ENSG00000136104ENST00000422660Q5TBB1
ENSG00000136104ENST00000611510A0A087WXR7
ENSG00000136104ENST00000616907A0A087WZJ6
ENSG00000136104ENST00000636524A0A1B0GTJ2
ENSG00000136104ENST00000637648A0A1B0GUE7
ENSG00000136104ENST00000642207A0A2R8Y7M7
ENSG00000136104ENST00000642454A0A2R8YEC1
ENSG00000136104ENST00000642721A0A2R8Y6Y1
ENSG00000136104ENST00000642995A0A2R8YCX2
ENSG00000136104ENST00000643159A0A2R8YEH2
ENSG00000136104ENST00000643215A0A2R8Y687
ENSG00000136104ENST00000643405A0A2R8Y459
ENSG00000136104ENST00000643462A0A2R8Y7A3
ENSG00000136104ENST00000643529A0A2R8YEU9
ENSG00000136104ENST00000643682A0A2R8YCJ4
ENSG00000136104ENST00000643774A0A2R8Y6Q6
ENSG00000136104ENST00000644034A0A2R8YEB4
ENSG00000136104ENST00000644183A0A2R8YEK5
ENSG00000136104ENST00000644297A0A2R8YEQ4
ENSG00000136104ENST00000644425A0A2R8YE60
ENSG00000136104ENST00000644518A0A2R8YEQ4
ENSG00000136104ENST00000645188A0A2R8YGP2
ENSG00000136104ENST00000645370A0A2R8Y4S2
ENSG00000136104ENST00000645618A0A2R8Y6M7
ENSG00000136104ENST00000645912A0A2R8Y4Y9
ENSG00000136104ENST00000645955A0A2R8Y761
ENSG00000136104ENST00000645990A0A2R8Y883
ENSG00000136104ENST00000646092A0A2R8Y7Q3
ENSG00000136104ENST00000646339A0A2R8Y6U1
ENSG00000136104ENST00000646709A0A087WXR7
ENSG00000136104ENST00000646731A0A2R8YCP1
ENSG00000136104ENST00000646960A0A2R8Y7R8
ENSG00000136104ENST00000647387A0A2R8YEC1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
DNA replicationKEGGhsa03030

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351799592022RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer.9
355008432022Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia.3
351799592022RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer.9
355008432022Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia.3
333535572020Germline variation of Ribonuclease H2 genes in ovarian cancer patients.0
333535572020Germline variation of Ribonuclease H2 genes in ovarian cancer patients.0
308892142019Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.4
308892142019Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.4
290307062017Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.11
290307062017Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.11
276436932016Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond.59
276436932016Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond.59
259069272015Genetics and molecular biology of brain calcification.17
259069272015Genetics and molecular biology of brain calcification.17
249869202014Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Goutières syndrome.23

Citation

Dessen P

RNASEH2B (ribonuclease H2 subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43055