SRCAP (Snf2 related CREBBP activator protein)

2005-11-01  

Identity

HGNC
SRCAP
LOCATION
16p11.2
LOCUSID
10847
ALIAS
DOMO1,EAF1,FLHS,SWR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10847
MIM: 611421
HGNC: 16974
Ensembl: ENSG00000080603

Variants:

dbSNP: 10847
ClinVar: 10847
TCGA: ENSG00000080603
COSMIC: SRCAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080603ENST00000262518Q6ZRS2
ENSG00000080603ENST00000395059A0A0A0MS59
ENSG00000080603ENST00000411466C9J4U4
ENSG00000080603ENST00000483083A0A087X0E3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378630542023SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.4
378630542023SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.4
351528382022LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP).2
351528382022LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP).2
333073432021Cancer-related SRCAP and TPR mutations in colon cancers.6
339099902021Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.26
341452292021Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.7
333073432021Cancer-related SRCAP and TPR mutations in colon cancers.6
339099902021Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.26
341452292021Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.7
303376832018Cryo-EM structure of human SRCAP complex.15
303376832018Cryo-EM structure of human SRCAP complex.15
291384932017Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.15
291384932017Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.15
272082102016When chromatin organisation floats astray: the Srcap gene and Floating-Harbor syndrome.16

Citation

Dessen P

SRCAP (Snf2 related CREBBP activator protein)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43068/favicon/gene-fusions-explorer/favicon/apple-touch-icon.png