SRCAP (Snf2 related CREBBP activator protein)

2005-11-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
DOMO1,EAF1,FLHS,SWR1
FUSION GENES

Other Information

Locus ID:

NCBI: 10847
MIM: 611421
HGNC: 16974
Ensembl: ENSG00000080603

Variants:

dbSNP: 10847
ClinVar: 10847
TCGA: ENSG00000080603
COSMIC: SRCAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080603ENST00000262518Q6ZRS2
ENSG00000080603ENST00000395059A0A0A0MS59
ENSG00000080603ENST00000411466C9J4U4
ENSG00000080603ENST00000483083A0A087X0E3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378630542023SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.4
378630542023SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.4
351528382022LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP).2
351528382022LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP).2
333073432021Cancer-related SRCAP and TPR mutations in colon cancers.6
339099902021Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.26
341452292021Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.7
333073432021Cancer-related SRCAP and TPR mutations in colon cancers.6
339099902021Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.26
341452292021Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.7
303376832018Cryo-EM structure of human SRCAP complex.15
303376832018Cryo-EM structure of human SRCAP complex.15
291384932017Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.15
291384932017Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.15
272082102016When chromatin organisation floats astray: the Srcap gene and Floating-Harbor syndrome.16

Citation

Dessen P

SRCAP (Snf2 related CREBBP activator protein)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43068/js/deep-insight-explorer/favicon/favicon-16x16.png