ALKBH4 (alkB homolog 4, lysine demethylase)

2006-05-01  

Identity

HGNC
ALKBH4
LOCATION
7q22.1
LOCUSID
54784
ALIAS
ABH4

Other Information

Locus ID:

NCBI: 54784
MIM: 613302
HGNC: 21900
Ensembl: ENSG00000160993

Variants:

dbSNP: 54784
ClinVar: 54784
TCGA: ENSG00000160993
COSMIC: ALKBH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160993ENST00000292566Q9NXW9
ENSG00000160993ENST00000490528Q9NXW9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375070182023ALKBH4 is a novel enzyme that promotes translation through modified uridine regulation.2
375070182023ALKBH4 is a novel enzyme that promotes translation through modified uridine regulation.2
349510992022Quantitative proteomics revealed new functions of ALKBH4.2
349510992022Quantitative proteomics revealed new functions of ALKBH4.2
338835772021ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer.7
338835772021ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer.7
236736172013ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.44
236736172013ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.44
231450622012Human ALKBH4 interacts with proteins associated with transcription.16
231450622012Human ALKBH4 interacts with proteins associated with transcription.16
211666552011Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4.14
211666552011Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4.14

Citation

Dessen P

ALKBH4 (alkB homolog 4, lysine demethylase)

Atlas Genet Cytogenet Oncol Haematol. 2006-05-01

Online version: http://atlasgeneticsoncology.org/gene/43078/alkbh4