ADA (adenosine deaminase)

2006-10-01  

Identity

HGNC
ADA
LOCATION
20q13.12
LOCUSID
100
ALIAS
ADA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 100
MIM: 608958
HGNC: 186
Ensembl: ENSG00000196839

Variants:

dbSNP: 100
ClinVar: 100
TCGA: ENSG00000196839
COSMIC: ADA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196839ENST00000372874P00813
ENSG00000196839ENST00000372874A0A0S2Z381
ENSG00000196839ENST00000536532F5GXW0
ENSG00000196839ENST00000537820F5GWI4
ENSG00000196839ENST00000539235F5GYD4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Primary immunodeficiencyKEGGko05340
Purine metabolismKEGGhsa00230
Primary immunodeficiencyKEGGhsa05340
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine salvageREACTOMER-HSA-74217

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376839022024Optimized expression and purification of a human adenosine deaminase in E. coli and characterization of its Asp8Asn variant.0
376950152024The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder.0
376839022024Optimized expression and purification of a human adenosine deaminase in E. coli and characterization of its Asp8Asn variant.0
376950152024The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder.0
365919052023Adenosine deaminase from the cerebrospinal fluid for the diagnosis of tuberculous meningitis: A meta-analysis.2
371165402023Identification of ADA as a Biomarker for Atypical Epstein Barr Virus Infection in Children.0
371271202023Correlation of serum adenosine deaminase activity with disease activity in patients with primary Sjögren's syndrome.1
371548622023Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China.1
376859492023Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019.2
365919052023Adenosine deaminase from the cerebrospinal fluid for the diagnosis of tuberculous meningitis: A meta-analysis.2
371165402023Identification of ADA as a Biomarker for Atypical Epstein Barr Virus Infection in Children.0
371271202023Correlation of serum adenosine deaminase activity with disease activity in patients with primary Sjögren's syndrome.1
371548622023Delayed-onset adenosine deaminase deficiency with a novel synonymous mutation and a case series from China.1
376859492023Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019.2
349132182022Does the adenosine deaminase (ADA) gene confer risk of sleepwalking?0

Citation

Dessen P

ADA (adenosine deaminase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43101