AK1 (adenylate kinase 1)

2006-10-01  

Identity

HGNC
AK1
LOCATION
9q34.11
LOCUSID
203
ALIAS
HTL-S-58j

Other Information

Locus ID:

NCBI: 203
MIM: 103000
HGNC: 361
Ensembl: ENSG00000106992

Variants:

dbSNP: 203
ClinVar: 203
TCGA: ENSG00000106992
COSMIC: AK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106992ENST00000223836Q5T9B7
ENSG00000106992ENST00000373156P00568
ENSG00000106992ENST00000373156Q6FGX9
ENSG00000106992ENST00000550143H0YID2
ENSG00000106992ENST00000550992F8VRY5
ENSG00000106992ENST00000644144P00568
ENSG00000106992ENST00000644144Q6FGX9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Thiamine metabolismKEGGko00730
Purine metabolismKEGGhsa00230
Thiamine metabolismKEGGhsa00730
Metabolic pathwaysKEGGhsa01100
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
325197442020High expression of AK1 predicts inferior prognosis in acute myeloid leukemia patients undergoing chemotherapy.5
325197442020High expression of AK1 predicts inferior prognosis in acute myeloid leukemia patients undergoing chemotherapy.5
309180132019Red cell adenylate kinase deficiency in India: identification of two novel missense mutations (c.71A>G and c.413G>A).3
314093842019DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.19
314443682019A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma.19
322515572019[Expressions of the adenylate kinase family in asthenospermia].0
309180132019Red cell adenylate kinase deficiency in India: identification of two novel missense mutations (c.71A>G and c.413G>A).3
314093842019DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.19
314443682019A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma.19
322515572019[Expressions of the adenylate kinase family in asthenospermia].0
244958782014The many isoforms of human adenylate kinases.70
244958782014The many isoforms of human adenylate kinases.70
231463162013Ak(1) genetic polymorphism and season of conception.1
238636342013AMPK, insulin resistance, and the metabolic syndrome.335
231463162013Ak(1) genetic polymorphism and season of conception.1

Citation

Dessen P

AK1 (adenylate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43111