ARF3 (ADP ribosylation factor 3)

2006-10-01  

Identity

HGNC
ARF3
LOCATION
12q13.12
LOCUSID
377
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 377
MIM: 103190
HGNC: 654
Ensembl: ENSG00000134287

Variants:

dbSNP: 377
ClinVar: 377
TCGA: ENSG00000134287
COSMIC: ARF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134287ENST00000256682P61204
ENSG00000134287ENST00000256682A0A024R0Y6
ENSG00000134287ENST00000447318P61204
ENSG00000134287ENST00000539611F5H6T5
ENSG00000134287ENST00000541236F5H0C7
ENSG00000134287ENST00000541959P61204
ENSG00000134287ENST00000541959A0A024R0Y6
ENSG00000134287ENST00000545855F5H1V1

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

References

Pubmed IDYearTitleCitations
368805952023The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels.3
368805952023The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels.3
363691692022Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.6
363691692022Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.6
280988972017Overexpression of ARF1 is associated with cell proliferation and migration through PI3K signal pathway in ovarian cancer.13
280988972017Overexpression of ARF1 is associated with cell proliferation and migration through PI3K signal pathway in ovarian cancer.13
263305662016Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.12
263305662016Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.12
260673732015ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking.9
260673732015ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking.9
237830332013ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.48
237830332013ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.48
229719772012ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.42
229719772012ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.42
203570022010Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors.33

Citation

Dessen P

ARF3 (ADP ribosylation factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43124/deep-insight-explorer/case-report-explorer/js/lib/zoomerang.js