ARHGEF7 (Rho guanine nucleotide exchange factor 7)

2006-10-01  

Identity

HGNC
ARHGEF7
LOCATION
13q34
LOCUSID
8874
ALIAS
BETA-PIX,COOL-1,COOL1,Nbla10314,P50,P50BP,P85,P85COOL1,P85SPR,PAK3,PIXB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8874
MIM: 605477
HGNC: 15607
Ensembl: ENSG00000102606

Variants:

dbSNP: 8874
ClinVar: 8874
TCGA: ENSG00000102606
COSMIC: ARHGEF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102606ENST00000218789B1ALK7
ENSG00000102606ENST00000317133Q14155
ENSG00000102606ENST00000375723Q14155
ENSG00000102606ENST00000375736Q14155
ENSG00000102606ENST00000375736A0A024RDY9
ENSG00000102606ENST00000375739Q14155
ENSG00000102606ENST00000375741Q14155
ENSG00000102606ENST00000426073Q14155
ENSG00000102606ENST00000426073A0A024RDY9
ENSG00000102606ENST00000426768E7ENL8
ENSG00000102606ENST00000449979B1ANY6
ENSG00000102606ENST00000466143E7EUY6
ENSG00000102606ENST00000467053C9JDI6
ENSG00000102606ENST00000469877E7EU80
ENSG00000102606ENST00000478679E9PDQ5
ENSG00000102606ENST00000491775C9JAD7
ENSG00000102606ENST00000544132F6SJA5
ENSG00000102606ENST00000646102A0A2R8YG42

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350855542022SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.2
350855542022SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.2
345820062021Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.1
345820062021Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.1
317542152020Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.12
321886982020ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.9
317542152020Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.12
321886982020ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.9
315664352019AMPK phosphorylation of the β(1)Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.4
315664352019AMPK phosphorylation of the β(1)Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.4
291919422018β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.7
292420612018Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.0
301325162018ARHGEF7 promotes metastasis of colorectal adenocarcinoma by regulating the motility of cancer cells.18
291919422018β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.7
292420612018Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.0

Citation

Dessen P

ARHGEF7 (Rho guanine nucleotide exchange factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43153/cancer-prone-explorer/case-report-explorer/js/_common.js