ARL1 (ADP ribosylation factor like GTPase 1)

2006-10-01  

Identity

HGNC
ARL1
LOCATION
12q23.2
LOCUSID
400
ALIAS
ARFL1

Other Information

Locus ID:

NCBI: 400
MIM: 603425
HGNC: 692
Ensembl: ENSG00000120805

Variants:

dbSNP: 400
ClinVar: 400
TCGA: ENSG00000120805
COSMIC: ARL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120805ENST00000261636P40616
ENSG00000120805ENST00000536227P40616
ENSG00000120805ENST00000539055B4DZG7
ENSG00000120805ENST00000548070F8VP99
ENSG00000120805ENST00000551092F8VP63
ENSG00000120805ENST00000551671F8VYN9
ENSG00000120805ENST00000551688F8W1Z8
ENSG00000120805ENST00000551828P40616

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
337152202021ArfGAP1 acts as a GTPase-activating protein for human ADP-ribosylation factor-like 1 protein.2
337152202021ArfGAP1 acts as a GTPase-activating protein for human ADP-ribosylation factor-like 1 protein.2
315756032019ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.0
315756032019ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.0
273731592016Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.17
273731592016Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.17
248354602014Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes.44
248354602014Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes.44
233454392013Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p.31
233454392013Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p.31
226790202012Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.0
226790202012Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.0
212394832011Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.25
212394832011Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.25
192249222009Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.0

Citation

Dessen P

ARL1 (ADP ribosylation factor like GTPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43155