ARL2 (ADP ribosylation factor like GTPase 2)

2006-10-01  

Identity

HGNC
ARL2
LOCATION
11q13.1
LOCUSID
402
ALIAS
ARFL2,MRCS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 402
MIM: 601175
HGNC: 693
Ensembl: ENSG00000213465

Variants:

dbSNP: 402
ClinVar: 402
TCGA: ENSG00000213465
COSMIC: ARL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213465ENST00000246747P36404
ENSG00000213465ENST00000246747Q53YD8
ENSG00000213465ENST00000529384P36404
ENSG00000213465ENST00000529384Q53YD8
ENSG00000213465ENST00000533729P36404

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355675022022ARL2 is required for homologous recombination repair and colon cancer stem cell survival.0
355675022022ARL2 is required for homologous recombination repair and colon cancer stem cell survival.0
324922242021Suppressed microRNA-195-5p expression in mycosis fungoides promotes tumor cell proliferation.4
324922242021Suppressed microRNA-195-5p expression in mycosis fungoides promotes tumor cell proliferation.4
308655552019ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2.12
309452702019Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.4
308655552019ELMOD2 regulates mitochondrial fusion in a mitofusin-dependent manner, downstream of ARL2.12
309452702019Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.4
298436372018ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL.18
298436372018ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL.18
281375902017miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells.24
289701042017Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.15
292659192017MicroRNA-497-5p Suppresses Tumor Cell Growth of Osteosarcoma by Targeting ADP Ribosylation Factor-Like Protein 2.0
281375902017miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells.24
289701042017Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.15

Citation

Dessen P

ARL2 (ADP ribosylation factor like GTPase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43156