NAIP (NLR family apoptosis inhibitory protein)

2007-02-01  

Identity

HGNC
NAIP
LOCATION
5q13.2
LOCUSID
4671
ALIAS
BIRC1,NLRB1,psiNAIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4671
MIM: 600355
HGNC: 7634
Ensembl: ENSG00000249437

Variants:

dbSNP: 4671
ClinVar: 4671
TCGA: ENSG00000249437
COSMIC: NAIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000249437ENST00000194097Q13075
ENSG00000249437ENST00000503719Q13075
ENSG00000249437ENST00000508426E7EQW0
ENSG00000249437ENST00000514857H0YAX2
ENSG00000249437ENST00000517649Q13075
ENSG00000249437ENST00000519014E5RJA3
ENSG00000249437ENST00000523981Q13075

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372672942023Pan-cancer analysis of the intervertebral-disc-degeneration-related innate immunity gene NAIP.0
375866422023Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.1
377506222023Deletions of SMNI gene exon 7 and NAIP gene exon 5 in spinal muscular atrophy patients in selected population.1
372672942023Pan-cancer analysis of the intervertebral-disc-degeneration-related innate immunity gene NAIP.0
375866422023Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.1
377506222023Deletions of SMNI gene exon 7 and NAIP gene exon 5 in spinal muscular atrophy patients in selected population.1
356785622022Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells.19
356785622022Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells.19
338462442021Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers.22
338462442021Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers.22
320114872020The analysis of the association between the copy numbers of survival motor neuron gene 2 and neuronal apoptosis inhibitory protein genes and the clinical phenotypes in 40 patients with spinal muscular atrophy: Observational study.8
320114872020The analysis of the association between the copy numbers of survival motor neuron gene 2 and neuronal apoptosis inhibitory protein genes and the clinical phenotypes in 40 patients with spinal muscular atrophy: Observational study.8
293116502018Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms.6
295181032018Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.16
293116502018Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms.6

Citation

Dessen P

NAIP (NLR family apoptosis inhibitory protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43168