BRSK2 (BR serine/threonine kinase 2)

2006-10-01  

Identity

HGNC
BRSK2
LOCATION
11p15.5
LOCUSID
9024
ALIAS
C11orf7,PEN11B,SAD1,SADA,STK29
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9024
MIM: 609236
HGNC: 11405
Ensembl: ENSG00000174672

Variants:

dbSNP: 9024
ClinVar: 9024
TCGA: ENSG00000174672
COSMIC: BRSK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174672ENST00000308219Q8IWQ3
ENSG00000174672ENST00000308219A0A140VJF6
ENSG00000174672ENST00000382179Q8IWQ3
ENSG00000174672ENST00000524702E9PPI2
ENSG00000174672ENST00000526678Q8IWQ3
ENSG00000174672ENST00000528596E9PRY3
ENSG00000174672ENST00000528710Q8IWQ3
ENSG00000174672ENST00000528841Q8IWQ3
ENSG00000174672ENST00000529433Q8IWQ3
ENSG00000174672ENST00000529433A0A024RCE9
ENSG00000174672ENST00000529951H0YCS6
ENSG00000174672ENST00000531197Q8IWQ3
ENSG00000174672ENST00000531197A0A024RCE9
ENSG00000174672ENST00000533606H0YES6
ENSG00000174672ENST00000544817A0A0C4DGH9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
371886472023BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.1
371886472023BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.1
335007142021STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway.18
335007142021STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway.18
308796382019Deleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder.14
308796382019Deleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder.14
285917202017BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.14
285917202017BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.14
239076672013BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.3
240476932013SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.5
239076672013BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.3
240476932013SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.5
226093992012Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.5
227134622012BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.11
227980682012Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.25

Citation

Dessen P

BRSK2 (BR serine/threonine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43174