CAMK2B (calcium/calmodulin dependent protein kinase II beta)

2006-10-01 Affiliation

Identity

HGNC

CAMK2B

LOCATION

7p13

LOCUSID

816

ALIAS

CAM2,CAMK2,CAMKB,CaMKIIbeta,MRD54

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 816
MIM: 607707
HGNC: 1461
Ensembl: ENSG00000058404

Variants:

dbSNP: 816
ClinVar: 816
TCGA: ENSG00000058404
COSMIC: CAMK2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000058404	ENST00000258682	Q13554
ENSG00000058404	ENST00000346990	Q13554
ENSG00000058404	ENST00000347193	Q13554
ENSG00000058404	ENST00000350811	Q13554
ENSG00000058404	ENST00000353185	H7BXS4
ENSG00000058404	ENST00000353625	Q13554
ENSG00000058404	ENST00000358707	Q13554
ENSG00000058404	ENST00000395747	Q13554
ENSG00000058404	ENST00000395749	Q13554
ENSG00000058404	ENST00000395749	A4D2J9
ENSG00000058404	ENST00000415369	E7EQE4
ENSG00000058404	ENST00000421607	E7ETC9
ENSG00000058404	ENST00000424197	E9PBE8
ENSG00000058404	ENST00000425809	H7C394
ENSG00000058404	ENST00000433930	H7BZC6
ENSG00000058404	ENST00000440254	Q13554
ENSG00000058404	ENST00000457475	Q13554
ENSG00000058404	ENST00000523845	E7ERS6

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
Calcium signaling pathway	KEGG	ko04020
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
Long-term potentiation	KEGG	ko04720
Olfactory transduction	KEGG	ko04740
GnRH signaling pathway	KEGG	ko04912
Melanogenesis	KEGG	ko04916
Glioma	KEGG	ko05214
ErbB signaling pathway	KEGG	hsa04012
Calcium signaling pathway	KEGG	hsa04020
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
Long-term potentiation	KEGG	hsa04720
Olfactory transduction	KEGG	hsa04740
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Glioma	KEGG	hsa05214
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Cholinergic synapse	KEGG	hsa04725
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
HIF-1 signaling pathway	KEGG	hsa04066
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Insulin secretion	KEGG	hsa04911
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activation	REACTOME	R-HSA-438066
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of Ras	REACTOME	R-HSA-442742
Ras activation uopn Ca2+ infux through NMDA receptor	REACTOME	R-HSA-442982
CREB phosphorylation through the activation of CaMKII	REACTOME	R-HSA-442729
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Muscle contraction	REACTOME	R-HSA-397014
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Ion transport by P-type ATPases	REACTOME	R-HSA-936837
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Cardiac conduction	REACTOME	R-HSA-5576891
Phase 0 - rapid depolarisation	REACTOME	R-HSA-5576892
Ion homeostasis	REACTOME	R-HSA-5578775
RET signaling	REACTOME	R-HSA-8853659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA248	NFKB1	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA36042	SP1	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37391113	2023	Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.	1
37391113	2023	Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.	1
32149607	2020	Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.	23
33019657	2020	CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.	21
32149607	2020	Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.	23
33019657	2020	CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.	21
29410121	2018	Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation.	11
29410121	2018	Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation.	11
28130256	2017	Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.	10
29100089	2017	De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.	75
28130256	2017	Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.	10
29100089	2017	De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.	75
25045698	2014	Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.	1
25045698	2014	Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.	1
22750393	2012	β-carotene reverses the IL-1β-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.	5

Citation

Dessen P

CAMK2B (calcium/calmodulin dependent protein kinase II beta)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43182