CDK3 (cyclin dependent kinase 3)

2006-10-01 Affiliation

Identity

HGNC

CDK3

LOCATION

17q25.1

LOCUSID

1018

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1018
MIM: 123828
HGNC: 1772
Ensembl: ENSG00000250506

Variants:

dbSNP: 1018
ClinVar: 1018
TCGA: ENSG00000250506
COSMIC: CDK3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000250506	ENST00000425876	Q00526
ENSG00000250506	ENST00000448471	Q00526
ENSG00000250506	ENST00000586261	K7EJ83
ENSG00000250506	ENST00000588812	K7ELV5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33504681	2021	circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene.	9
33504681	2021	circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene.	9
28939591	2018	miR-125a-3p inhibits ERα transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor-positive breast cancer.	24
29344850	2018	HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.	22
28939591	2018	miR-125a-3p inhibits ERα transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor-positive breast cancer.	24
29344850	2018	HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.	22
27893713	2017	Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer.	16
28108217	2017	CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect.	3
28501005	2017	HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.	30
27893713	2017	Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer.	16
28108217	2017	CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect.	3
28501005	2017	HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.	30
26498144	2016	miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators.	15
26755651	2016	Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis.	17
26498144	2016	miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators.	15

Citation

Dessen P

CDK3 (cyclin dependent kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43201