Identity
HGNC
LOCATION
1q44
LOCUSID
ALIAS
AGTAVPRL,AII,AVP,C1orf7,CIAS1,CLR1.1,DFNA34,FCAS,FCAS1,FCU,KEFH,MWS,NALP3,PYPAF1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 114548
MIM: 606416
HGNC: 16400
Ensembl: ENSG00000162711
Variants:
dbSNP: 114548
ClinVar: 114548
TCGA: ENSG00000162711
COSMIC: NLRP3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36412004 | 2024 | Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway. | 1 |
| 37057822 | 2024 | Decreased survival in patients with pancreatic cancer may be associated with an increase in histopathological expression of inflammasome marker NLRP3. | 6 |
| 37481715 | 2024 | Pyrin variant E148Q potentiates inflammasome activation and the effect of pathogenic mutations in cis. | 0 |
| 37665559 | 2024 | MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis. | 1 |
| 37738164 | 2024 | Discovery of a Novel Missense Variant in NLRP3 Causing Atypical Cryopyrin-Associated Periodic Syndromes With Hearing Loss as the Primary Presentation, Responsive to Anti-Interleukin-1 Therapy. | 1 |
| 37748021 | 2024 | NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases. | 1 |
| 37815748 | 2024 | NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome. | 0 |
| 37871673 | 2024 | NLRP3 inflammatory pathway. Can we unlock depression? | 1 |
| 37923829 | 2024 | The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases. | 12 |
| 37948033 | 2024 | Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease. | 1 |
| 38043434 | 2024 | NLRP3 inflammasome pathway, the hidden balance in pregnancy: A comprehensive review. | 0 |
| 38146057 | 2024 | The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity. | 1 |
| 38172822 | 2024 | Inter-relationships of galectin-3 and NLR family pyrin domain containing 3 inflammasomes with oral lichen planus: a preliminary cross-sectional in vitro study. | 0 |
| 38216560 | 2024 | Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity. | 0 |
| 38218765 | 2024 | Increased expression of NLRP3 associated with elevated levels of HMGB1 in children with febrile seizures: a case-control study. | 0 |
Citation
Dessen P
NLRP3 (NLR family pyrin domain containing 3)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43213/nlrp3
