CSNK2A1 (casein kinase 2 alpha 1)

2006-10-01  

Identity

HGNC
CSNK2A1
LOCATION
20p13
LOCUSID
1457
ALIAS
CK2A1,CKII,Cka1,Cka2,OCNDS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1457
MIM: 115440
HGNC: 2457
Ensembl: ENSG00000101266

Variants:

dbSNP: 1457
ClinVar: 1457
TCGA: ENSG00000101266
COSMIC: CSNK2A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101266ENST00000217244P68400
ENSG00000101266ENST00000349736P68400
ENSG00000101266ENST00000400217P68400
ENSG00000101266ENST00000400227E7EU96
ENSG00000101266ENST00000460062V9GYW6
ENSG00000101266ENST00000608066V9GY80
ENSG00000101266ENST00000609525V9GYA2
ENSG00000101266ENST00000619801A0A087WY74
ENSG00000101266ENST00000642160A0A2R8Y797
ENSG00000101266ENST00000642689A0A2R8YFU2
ENSG00000101266ENST00000643600A0A2R8Y4H0
ENSG00000101266ENST00000643660P68400
ENSG00000101266ENST00000643680A0A2R8Y4D6
ENSG00000101266ENST00000643910A0A2R8YCC9
ENSG00000101266ENST00000643968A0A2R8YCK2
ENSG00000101266ENST00000644003P68400
ENSG00000101266ENST00000644177A0A2R8YDY7
ENSG00000101266ENST00000644710A0A2R8YFU2
ENSG00000101266ENST00000644885A0A2R8YF43
ENSG00000101266ENST00000645091A0A2R8YEW1
ENSG00000101266ENST00000645187A0A2R8Y7T1
ENSG00000101266ENST00000645234A0A2R8YD58
ENSG00000101266ENST00000645249A0A2R8YF47
ENSG00000101266ENST00000645260A0A2R8YDP2
ENSG00000101266ENST00000645623P68400
ENSG00000101266ENST00000645840A0A2R8YEL7
ENSG00000101266ENST00000645910A0A2R8YCK2
ENSG00000101266ENST00000646305P68400
ENSG00000101266ENST00000646477P68400
ENSG00000101266ENST00000646561P68400
ENSG00000101266ENST00000646814P68400
ENSG00000101266ENST00000646908A0A2R8Y3W6
ENSG00000101266ENST00000647026A0A2R8Y5A0
ENSG00000101266ENST00000647348P68400

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
WNT mediated activation of DVLREACTOMER-HSA-201688
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Condensation of Prometaphase ChromosomesREACTOMER-HSA-2514853
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PCREACTOMER-HSA-1483191
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Signal transduction by L1REACTOMER-HSA-445144
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382906592024CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.0
384442592024Okur-Chung neurodevelopmental syndrome: Implications for phenotype and genotype expansion.1
382906592024CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.0
384442592024Okur-Chung neurodevelopmental syndrome: Implications for phenotype and genotype expansion.1
373910102023P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis.1
375248742023SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.2
377775112023A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution.3
373910102023P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis.1
375248742023SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.2
377775112023A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution.3
351638092022Long Non-Coding RNA KCNQ1OT1 Regulates Protein Kinase CK2 Via miR-760 in Senescence and Calorie Restriction.4
352462692022Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization.5
365527542022CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca(2+) via Mitochondrial NCLX.2
351638092022Long Non-Coding RNA KCNQ1OT1 Regulates Protein Kinase CK2 Via miR-760 in Senescence and Calorie Restriction.4
352462692022Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization.5

Citation

Dessen P

CSNK2A1 (casein kinase 2 alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43221/css/lib/haematological-explorer/favicon/apple-touch-icon.png