CYC1 (cytochrome c1)

2006-10-01  

Identity

HGNC
CYC1
LOCATION
8q24.3
LOCUSID
1537
ALIAS
MC3DN6,UQCR4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1537
MIM: 123980
HGNC: 2579
Ensembl: ENSG00000179091

Variants:

dbSNP: 1537
ClinVar: 1537
TCGA: ENSG00000179091
COSMIC: CYC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179091ENST00000318911P08574

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Metabolic pathwaysKEGGhsa01100
Cytochrome bc1 complex respiratory unitKEGGhsa_M00151
Cytochrome bc1 complexKEGGhsa_M00152
Cytochrome bc1 complex respiratory unitKEGGM00151
Cytochrome bc1 complexKEGGM00152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
327172232020Physical contact between cytochrome c(1) and cytochrome c increases the driving force for electron transfer.5
327172232020Physical contact between cytochrome c(1) and cytochrome c increases the driving force for electron transfer.5
311497282019Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.3
311497282019Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.3
283912622017MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.4
283944732017Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.8
283912622017MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.4
283944732017Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.8
271176632016Apoptosis Markers in Breast Cancer Therapy.17
272390882016CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.11
271176632016Apoptosis Markers in Breast Cancer Therapy.17
272390882016CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.11
255621552014CYC1 silencing sensitizes osteosarcoma cells to TRAIL-induced apoptosis.14
255621552014CYC1 silencing sensitizes osteosarcoma cells to TRAIL-induced apoptosis.14
239104602013Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia.28

Citation

Dessen P

CYC1 (cytochrome c1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43222