DCLK1 (doublecortin like kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
13q13.3
LOCUSID
ALIAS
CL1,CLICK1,DCAMKL1,DCDC3A,DCLK
FUSION GENES

Other Information

Locus ID:

NCBI: 9201
MIM: 604742
HGNC: 2700
Ensembl: ENSG00000133083

Variants:

dbSNP: 9201
ClinVar: 9201
TCGA: ENSG00000133083
COSMIC: DCLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133083ENST00000255448O15075
ENSG00000133083ENST00000360631O15075
ENSG00000133083ENST00000379892Q5VZY9
ENSG00000133083ENST00000379893O15075
ENSG00000133083ENST00000615680O15075

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380071472024DCLK1 and its oncogenic functions: A promising therapeutic target for cancers.1
388215832024DCLK1 Expression and its Functional Significance in Intrahepatic Cholangiocarcinoma and Bil-IN Stage.0
380071472024DCLK1 and its oncogenic functions: A promising therapeutic target for cancers.1
388215832024DCLK1 Expression and its Functional Significance in Intrahepatic Cholangiocarcinoma and Bil-IN Stage.0
362182312023Doublecortin-like kinase 1 is a therapeutic target in squamous cell carcinoma.4
370696692023Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling.6
374620162023[Doublecortin-like kinase 1 activates Hippo pathway to promote migration, invasion and proliferation of pancreatic cancer cells].0
374872552023Exosomes from metastatic colon cancer cells drive the proliferation and migration of primary colon cancer through increased expression of cancer stem cell markers CD133 and DCLK1.4
379967822023Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.0
362182312023Doublecortin-like kinase 1 is a therapeutic target in squamous cell carcinoma.4
370696692023Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling.6
374620162023[Doublecortin-like kinase 1 activates Hippo pathway to promote migration, invasion and proliferation of pancreatic cancer cells].0
374872552023Exosomes from metastatic colon cancer cells drive the proliferation and migration of primary colon cancer through increased expression of cancer stem cell markers CD133 and DCLK1.4
379967822023Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.0
355229022022Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness.9

Citation

Dessen P

DCLK1 (doublecortin like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43223/css/gene-explorer/js/lib/jquery-3.5.1.min.js