DUT (deoxyuridine triphosphatase)

2006-10-01  

Identity

HGNC
DUT
LOCATION
15q21.1
LOCUSID
1854
ALIAS
dUTPase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1854
MIM: 601266
HGNC: 3078
Ensembl: ENSG00000128951

Variants:

dbSNP: 1854
ClinVar: 1854
TCGA: ENSG00000128951
COSMIC: DUT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128951ENST00000331200P33316
ENSG00000128951ENST00000455976P33316
ENSG00000128951ENST00000558367H0YMP1
ENSG00000128951ENST00000558472H0YKC5
ENSG00000128951ENST00000558813A0A0C4DGL3
ENSG00000128951ENST00000558978H0YKI0
ENSG00000128951ENST00000559416H0YNW5
ENSG00000128951ENST00000559540H0YNJ9
ENSG00000128951ENST00000559935H0YMM5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine biosynthesisREACTOMER-HSA-500753

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371733372023Discovery of two new isoforms of the human DUT gene.1
371733372023Discovery of two new isoforms of the human DUT gene.1
364269242022DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma.0
364269242022DUT enhances drug resistance to proteasome inhibitors via promoting mitochondrial function in multiple myeloma.0
345841842021Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability.0
345841842021Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability.0
306795362019Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk.0
306795362019Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk.0
295313482018Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.11
295313482018Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.11
280738292017dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.11
280738292017dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.11
238945492013Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells.48
243115902013Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.18
238945492013Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells.48

Citation

Dessen P

DUT (deoxyuridine triphosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43233