Identity
HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
IRE1,IRE1P,IRE1a,hIRE1p
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2081
MIM: 604033
HGNC: 3449
Ensembl: ENSG00000178607
Variants:
dbSNP: 2081
ClinVar: 2081
TCGA: ENSG00000178607
COSMIC: ERN1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178607 | ENST00000433197 | O75460 |
| ENSG00000178607 | ENST00000606895 | O75460 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38071801 | 2024 | Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown. | 1 |
| 38146001 | 2024 | Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia. | 0 |
| 38563293 | 2024 | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells. | 0 |
| 38578285 | 2024 | IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response. | 0 |
| 38648902 | 2024 | The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection. | 0 |
| 38656254 | 2024 | Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells. | 0 |
| 38727283 | 2024 | TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2. | 0 |
| 38071801 | 2024 | Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown. | 1 |
| 38146001 | 2024 | Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia. | 0 |
| 38563293 | 2024 | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells. | 0 |
| 38578285 | 2024 | IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response. | 0 |
| 38648902 | 2024 | The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection. | 0 |
| 38656254 | 2024 | Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells. | 0 |
| 38727283 | 2024 | TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2. | 0 |
| 36624093 | 2023 | Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer. | 7 |
Citation
Dessen P
ERN1 (endoplasmic reticulum to nucleus signaling 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43247/ern1
