Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9700
MIM: 604143
HGNC: 16856
Ensembl: ENSG00000135476
Variants:
dbSNP: 9700
ClinVar: 9700
TCGA: ENSG00000135476
COSMIC: ESPL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135476 | ENST00000257934 | Q14674 |
| ENSG00000135476 | ENST00000552671 | H3BM31 |
| ENSG00000135476 | ENST00000553219 | H3BRX7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38568742 | 2024 | Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer. | 1 |
| 38568742 | 2024 | Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer. | 1 |
| 37140261 | 2023 | The molecular mechanisms of human separase regulation. | 0 |
| 37140261 | 2023 | The molecular mechanisms of human separase regulation. | 0 |
| 34180834 | 2021 | [Separase, a key-player of mitosis: A new target for cancer therapy?]. | 1 |
| 34290405 | 2021 | Structural basis of human separase regulation by securin and CDK1-cyclin B1. | 35 |
| 34180834 | 2021 | [Separase, a key-player of mitosis: A new target for cancer therapy?]. | 1 |
| 34290405 | 2021 | Structural basis of human separase regulation by securin and CDK1-cyclin B1. | 35 |
| 32253454 | 2020 | Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients. | 3 |
| 32322059 | 2020 | Separase-triggered apoptosis enforces minimal length of mitosis. | 14 |
| 32322060 | 2020 | Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2. | 21 |
| 32574725 | 2020 | Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants. | 6 |
| 33282948 | 2020 | TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. | 13 |
| 33308056 | 2020 | Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study. | 3 |
| 32253454 | 2020 | Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients. | 3 |
Citation
Dessen P
ESPL1 (extra spindle pole bodies like 1, separase)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43249/espl1
