GNA13 (G protein subunit alpha 13)

2006-10-01 Affiliation

Identity

HGNC

GNA13

LOCATION

17q24.1

LOCUSID

10672

ALIAS

G13

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10672
MIM: 604406
HGNC: 4381
Ensembl: ENSG00000120063

Variants:

dbSNP: 10672
ClinVar: 10672
TCGA: ENSG00000120063
COSMIC: GNA13

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120063	ENST00000439174	Q14344
ENSG00000120063	ENST00000439174	A0A024R8M0
ENSG00000120063	ENST00000541118	Q14344

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Long-term depression	KEGG	ko04730
Regulation of actin cytoskeleton	KEGG	ko04810
Long-term depression	KEGG	hsa04730
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Platelet activation	KEGG	hsa04611
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
Thromboxane signalling through TP receptor	REACTOME	R-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)	REACTOME	R-HSA-456926
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA131285527	oxaliplatin	Chemical	MultilinkAnnotation	associated	24444404
PA27946	F2R	Gene	Pathway	associated	20938371
PA27949	F2RL3	Gene	Pathway	associated	20938371
PA32868	P2RY1	Gene	Pathway	associated	20938371
PA33384	PLCB1	Gene	Pathway	associated	20938371
PA33393	PLCG2	Gene	Pathway	associated	20938371
PA348	TBXA2R	Gene	Pathway	associated	20938371

References

Pubmed ID	Year	Title	Citations
38357893	2024	The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.	0
38357893	2024	The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.	0
36442589	2023	Overexpressed Gα13 activates serum response factor through stoichiometric imbalance with Gβγ and mislocalization to the cytoplasm.	0
36442589	2023	Overexpressed Gα13 activates serum response factor through stoichiometric imbalance with Gβγ and mislocalization to the cytoplasm.	0
33423045	2021	GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.	10
33423045	2021	GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.	10
31676466	2020	The role of genes affected by human evolution marker GNA13 in schizophrenia.	2
32330601	2020	Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation.	2
32778842	2020	G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.	23
33023908	2020	Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42.	11
33109615	2020	Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling.	13
31676466	2020	The role of genes affected by human evolution marker GNA13 in schizophrenia.	2
32330601	2020	Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation.	2
32778842	2020	G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.	23
33023908	2020	Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42.	11

Citation

Dessen P

GNA13 (G protein subunit alpha 13)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43273/case-report-explorer/gene-fusions/favicon/manifest.json