GNA14 (G protein subunit alpha 14)

2006-10-01  

Identity

HGNC
LOCATION
9q21.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9630
MIM: 604397
HGNC: 4382
Ensembl: ENSG00000156049

Variants:

dbSNP: 9630
ClinVar: 9630
TCGA: ENSG00000156049
COSMIC: GNA14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156049ENST00000341700O95837

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Acetylcholine regulates insulin secretionREACTOMER-HSA-399997
Free fatty acids regulate insulin secretionREACTOMER-HSA-400451
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionREACTOMER-HSA-434316

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
335007272021Hypermethylation of GNA14 and its tumor-suppressive role in hepatitis B virus-related hepatocellular carcinoma.16
338926672021GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2.5
346571502021GNA14's interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway.7
335007272021Hypermethylation of GNA14 and its tumor-suppressive role in hepatitis B virus-related hepatocellular carcinoma.16
338926672021GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2.5
346571502021GNA14's interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway.7
303215922019Arginine 313 of the putative 8th helix mediates Gα(q/14) coupling of human CC chemokine receptors CCR2a and CCR2b.5
303871492019G Protein α Subunit 14 Mediates Fibroblast Growth Factor 2-Induced Cellular Responses in Human Endothelial Cells.7
311899942019High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.13
303215922019Arginine 313 of the putative 8th helix mediates Gα(q/14) coupling of human CC chemokine receptors CCR2a and CCR2b.5
303871492019G Protein α Subunit 14 Mediates Fibroblast Growth Factor 2-Induced Cellular Responses in Human Endothelial Cells.7
311899942019High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.13
295749262018Recurrent GNA14 mutations in anastomosing haemangiomas.15
299752482018Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm.32
300544232018GNA14 silencing suppresses the proliferation of endometrial carcinoma cells through inducing apoptosis and G(2)/M cell cycle arrest.5

Citation

Dessen P

GNA14 (G protein subunit alpha 14)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43274/gna14