GNA15 (G protein subunit alpha 15)

2006-10-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
GNA16
FUSION GENES

Other Information

Locus ID:

NCBI: 2769
MIM: 139314
HGNC: 4383
Ensembl: ENSG00000060558

Variants:

dbSNP: 2769
ClinVar: 2769
TCGA: ENSG00000060558
COSMIC: GNA15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060558ENST00000262958P30679
ENSG00000060558ENST00000592455K7EP74

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Calcium signaling pathwayKEGGhsa04020
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 1REACTOMER-HSA-418592
Thromboxane signalling through TP receptorREACTOMER-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)REACTOMER-HSA-456926
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Acetylcholine regulates insulin secretionREACTOMER-HSA-399997
Free fatty acids regulate insulin secretionREACTOMER-HSA-400451
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionREACTOMER-HSA-434316

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA27946F2RGenePathwayassociated20938371
PA27949F2RL3GenePathwayassociated20938371
PA32868P2RY1GenePathwayassociated20938371
PA33384PLCB1GenePathwayassociated20938371
PA33393PLCG2GenePathwayassociated20938371
PA348TBXA2RGenePathwayassociated20938371

References

Pubmed IDYearTitleCitations
366421122023Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.8
366421122023Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.8
257015392015GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses.7
257015392015GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses.7
232008472013Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction.4
242046972013Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.9
232008472013Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction.4
242046972013Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.9
222272482012Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.17
222272482012Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.17
214864972011Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.3
214864972011Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.3
201503272010The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis.15
201503272010The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis.15
192759342009Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.4

Citation

Dessen P

GNA15 (G protein subunit alpha 15)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43275/cancer-prone-explorer/css/lib/gene-explorer/