GNA15 (G protein subunit alpha 15)

2006-10-01 Affiliation

Identity

HGNC

GNA15

LOCATION

19p13.3

LOCUSID

2769

ALIAS

GNA16

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2769
MIM: 139314
HGNC: 4383
Ensembl: ENSG00000060558

Variants:

dbSNP: 2769
ClinVar: 2769
TCGA: ENSG00000060558
COSMIC: GNA15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000060558	ENST00000262958	P30679
ENSG00000060558	ENST00000592455	K7EP74

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Calcium signaling pathway	KEGG	hsa04020
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
ADP signalling through P2Y purinoceptor 1	REACTOME	R-HSA-418592
Thromboxane signalling through TP receptor	REACTOME	R-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)	REACTOME	R-HSA-456926
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Acetylcholine regulates insulin secretion	REACTOME	R-HSA-399997
Free fatty acids regulate insulin secretion	REACTOME	R-HSA-400451
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME	R-HSA-434316

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA27946	F2R	Gene	Pathway	associated	20938371
PA27949	F2RL3	Gene	Pathway	associated	20938371
PA32868	P2RY1	Gene	Pathway	associated	20938371
PA33384	PLCB1	Gene	Pathway	associated	20938371
PA33393	PLCG2	Gene	Pathway	associated	20938371
PA348	TBXA2R	Gene	Pathway	associated	20938371

References

Pubmed ID	Year	Title	Citations
36642112	2023	Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.	8
36642112	2023	Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15.	8
25701539	2015	GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses.	7
25701539	2015	GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses.	7
23200847	2013	Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction.	4
24204697	2013	Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.	9
23200847	2013	Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction.	4
24204697	2013	Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.	9
22227248	2012	Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.	17
22227248	2012	Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.	17
21486497	2011	Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.	3
21486497	2011	Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.	3
20150327	2010	The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis.	15
20150327	2010	The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis.	15
19275934	2009	Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.	4

Citation

Dessen P

GNA15 (G protein subunit alpha 15)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43275/js/haematological-explorer/favicon/favicon-16x16.png